Interactor 1: RIR2 (P31350)
Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)
Gene: RRM2

Interactor 2: RIR2B (Q7LG56)
Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)
Gene: RRM2B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.861

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Ribonuc_red_sm~Ribonuc_red_sm
Common GO terms GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005829 - cytosol
GO:0005971 - ribonucleoside-diphosphate reductase complex
GO:0009185 - ribonucleoside diphosphate metabolic process
GO:0009263 - deoxyribonucleotide biosynthetic process
and 1 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 389
Hs

1 351
+ Hs
+ Hs
+ Vv
+ Sc
+ Ce
+ Sc
+ Sc
+ Hh
+ Hh
+ Hh
+ Ha
+ Ec
+ Ec
+ Mp
+ Mt

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Last updated: 15 Jul 2024