HitPredict

Interactor 1: TIA1 (P31483)
Cytotoxic granule associated RNA binding protein TIA1 (Nucleolysin TIA-1 isoform p40) (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) (p40-TIA-1)
Gene: TIA1

Interactor 2: SRSF3 (P84103)
Serine/arginine-rich splicing factor 3 (Pre-mRNA-splicing factor SRP20) (Splicing factor, arginine/serine-rich 3)
Gene: SRSF3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	27381497
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0048024 - regulation of mRNA splicing, via spliceosome
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 386 Hs			1 164
+	Mm
		857340 TIA1_MOUSE (1-386): 1.13e-110: 330: 96.63		SRSF1_MOUSE (9-80): 1.1e-25: 100: 48.65
+	Mm
		665745 TIA1_MOUSE (1-386): 1.13e-110: 330: 96.63		PABP1_MOUSE (1-91): 1.3e-20: 89.2: 25.77
+	Hs
		680422 TIA1_HUMAN (1-386): 3.24e-111: 332: 100.00		TIA1_HUMAN (5-107): 1.38e-18: 83: 21.70
+	Hs
		680439 TIA1_HUMAN (1-386): 3.24e-111: 332: 100.00		TIAR_HUMAN (1-95): 5.6e-18: 81.1: 26.00
+	Hs
		516471 TIAR_HUMAN (1-386): 5.19e-88: 272: 73.01		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Mm
		936481 TIAR_MOUSE (1-386): 2.77e-83: 260: 68.97		SRSF1_MOUSE (9-80): 1.1e-25: 100: 48.65
+	Hs
		963504 TIAR_HUMAN (1-386): 5.19e-88: 272: 73.01		TIAR_HUMAN (1-95): 5.6e-18: 81.1: 26.00
+	Hs
		992875 PABP5_HUMAN (2-187): 2.52e-44: 159: 22.63		SRSF1_HUMAN (9-80): 1.1e-25: 100: 48.65
+	Hs
		267046 PABP5_HUMAN (2-187): 2.52e-44: 159: 22.63		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		1119141 PABP5_HUMAN (2-187): 2.52e-44: 159: 22.63		PAP1L_HUMAN (1-94): 4.25e-21: 90.7: 22.55
+	Hs
		516635 PABP5_HUMAN (2-187): 2.52e-44: 159: 22.63		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		1028593 PABP5_HUMAN (2-187): 2.52e-44: 159: 22.63		SRSF9_HUMAN (9-82): 1.91e-19: 83.2: 40.79
+	Hs
		474017 PAB4L_HUMAN (104-299): 1.73e-34: 132: 24.00		SRSF3_HUMAN (1-164): 6.39e-27: 100: 100.00
+	Hs
		266904 PABP1_HUMAN (96-297): 6.74e-33: 131: 26.70		SRS10_HUMAN (1-164): 2.25e-24: 96.6: 32.54
+	Hs
		516425 PABP1_HUMAN (96-297): 6.74e-33: 131: 26.70		NCBP2_HUMAN (7-117): 3.6e-25: 96.1: 24.14
+	Hs
		474021 PAB4L_HUMAN (104-299): 1.73e-34: 132: 24.00		PABP4_HUMAN (5-91): 1.61e-21: 91.9: 26.09
+	Hs
		516339 PABP1_HUMAN (96-297): 6.74e-33: 131: 26.70		PABP1_HUMAN (1-91): 1.13e-20: 89.6: 25.77
+	Hs
		474020 PAB4L_HUMAN (104-299): 1.73e-34: 132: 24.00		SRSF6_HUMAN (11-88): 3.86e-16: 75.8: 47.44