HitPredict

Interactor 1: HS104 (P31539)
Heat shock protein 104 (Protein aggregation-remodeling factor HSP104)
Gene: HSP104

Interactor 2: HSP78 (P33416)
Heat shock protein 78, mitochondrial
Gene: HSP78

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	36704946, 37968396, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AAA~AAA, AAA~AAA_2, AAA~AAA_lid_9, AAA~ClpB_D2-small, AAA_2~AAA_2, AAA_2~AAA_lid_9, AAA_2~ClpB_D2-small, AAA_lid_9~AAA_lid_9, AAA_lid_9~ClpB_D2-small, AAA~Clp_N, AAA_lid_9~Clp_N, ClpB_D2-small~ClpB_D2-small
Common GO terms	GO:0005524 - ATP binding GO:0005737 - cytoplasm GO:0016887 - ATP hydrolysis activity GO:0042026 - protein refolding GO:0043335 - protein unfolding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 908 Sc			1 811
+	Ec
		930511 CLPB_ECOLI (5-863): 0: 891: 42.43		CLPB_ECOLI (7-796): 0: 647: 47.35
+	Tt
		1351695 CLPB_THET8 (3-866): 0: 847: 43.22		CLPB_THET8 (2-795): 0: 629: 49.18
+	Sp
		293888 HS104_SCHPO (7-867): 0: 854: 51.94		HS104_SCHPO (3-807): 0: 608: 45.80
+	Sc
		680504 HS104_YEAST (1-908): 0: 893: 100.00		HS104_YEAST (1-809): 0: 554: 40.98
+	Pf
		1212793 Q8IIJ8_PLAF7 (3-873): 0: 691: 35.24		Q8IIJ8_PLAF7 (14-798): 1.05e-170: 517: 35.04
+	Sc
		681040 HS104_YEAST (1-908): 0: 893: 100.00		RIX7_YEAST (357-762): 1.6e-24: 111: 12.26
+	Sc
		705724 HSP78_YEAST (103-867): 0: 747: 42.53		RIX7_YEAST (357-762): 1.6e-24: 111: 12.26
+	Hs
		737476 LONM_HUMAN (326-881): 1.99e-80: 282: 13.84		CLPB_HUMAN (498-811): 5.49e-70: 246: 35.59
+	Cj
		1007187 Q0P9E6_CAMJE (451-864): 5.46e-85: 289: 30.62		Q0P9E6_CAMJE (6-411): 8.52e-62: 223: 32.60