HitPredict

Interactor 1: HS104 (P31539)
Heat shock protein 104 (Protein aggregation-remodeling factor HSP104)
Gene: HSP104

Interactor 2: PRS10 (P53549)
26S proteasome subunit RPT4 (26S protease subunit SUG2) (Proteasomal cap subunit)
Gene: RPT4

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.54	1.00	0.737

Property	Details
Experiments	27373154, 19536198
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AAA~AAA, AAA~AAA_lid_3, AAA~Prot_ATP_ID_OB, AAA~AAA_2, AAA~AAA_lid_9, AAA~Clp_N, AAA~ClpB_D2-small
Common GO terms	GO:0005524 - ATP binding GO:0005634 - nucleus GO:0016887 - ATP hydrolysis activity
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 908 Sc			1 437
+	Sc
		680937 HS104_YEAST (1-908): 0: 893: 100.00		PRS8_YEAST (73-437): 2.68e-99: 304: 44.89
+	Sc
		680575 HS104_YEAST (1-908): 0: 893: 100.00		PRS7_YEAST (116-436): 9.22e-93: 289: 46.89
+	Sc
		636555 HS104_YEAST (1-908): 0: 893: 100.00		CDC48_YEAST (3-414): 2.64e-82: 271: 28.04
+	Sc
		705546 HSP78_YEAST (103-867): 0: 747: 42.53		PRS8_YEAST (73-437): 2.68e-99: 304: 44.89
+	Sc
		636577 HSP78_YEAST (103-867): 0: 747: 42.53		CDC48_YEAST (3-414): 2.64e-82: 271: 28.04
+	Zm
		6956 A0A1D6EC46_MAIZE (4-869): 0: 695: 28.05		K7VQA7_MAIZE (167-414): 7.25e-78: 259: 40.32
+	Zm
		32521 K7TGQ6_MAIZE (3-750): 1.1e-103: 347: 17.23		A0A1D6KUI9_MAIZE (1-433): 3.79e-78: 260: 24.57