HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.670

The method score is based on:

Property	Details
Experiments	19122674, 18191226, 19262695
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001934 - positive regulation of protein phosphorylation GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol and 9 others more... GO:0005886 - plasma membrane GO:0010628 - positive regulation of gene expression GO:0016567 - protein ubiquitination GO:0019899 - enzyme binding GO:0031397 - negative regulation of protein ubiquitination GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process GO:0060079 - excitatory postsynaptic potential GO:0098794 - postsynapse GO:0098978 - glutamatergic synapse
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1	480
Hs

1	409

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024