HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: TCPB (P78371)
T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta) (Chaperonin containing T-complex polypeptide 1 subunit 2)
Gene: CCT2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.641

Property	Details
Experiments	31980649, 34941261, unassigned2173
Identification Methods	affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 535
+	Hs
		681999 AKT1_HUMAN (1-480): 0: 586: 100.00		TCPH_HUMAN (4-532): 0: 591: 34.08
+	Hs
		681738 AKT1_HUMAN (1-480): 0: 586: 100.00		TCPG_HUMAN (3-532): 0: 561: 28.33
+	Hs
		573141 AKT1_HUMAN (1-480): 0: 586: 100.00		TCPA_HUMAN (5-533): 0: 541: 34.30
+	Hs
		681735 AKT1_HUMAN (1-480): 0: 586: 100.00		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Dm
		1213438 AKT1_DROME (3-474): 0: 523: 60.37		Q9W392_DROME (4-535): 0: 568: 70.73
+	Dm
		1213398 AKT1_DROME (3-474): 0: 523: 60.37		Q9VHL2_DROME (5-525): 0: 554: 31.75
+	Hs
		1306721 KS6B2_HUMAN (129-479): 4.6e-147: 430: 42.25		TCPH_HUMAN (4-532): 0: 591: 34.08
+	Hs
		1306691 SGK2_HUMAN (122-475): 1.02e-147: 428: 47.75		TCPH_HUMAN (4-532): 0: 591: 34.08
+	Hs
		943525 KS6B2_HUMAN (129-479): 4.6e-147: 430: 42.25		TCPB_HUMAN (1-535): 0: 586: 100.00
+	Hs
		568623 KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53		TCPB_HUMAN (1-535): 0: 586: 100.00
+	Hs
		826928 KS6B2_HUMAN (129-479): 4.6e-147: 430: 42.25		TCPG_HUMAN (3-532): 0: 561: 28.33
+	Hs
		826897 SGK2_HUMAN (122-475): 1.02e-147: 428: 47.75		TCPG_HUMAN (3-532): 0: 561: 28.33
+	Hs
		573515 KS6B2_HUMAN (129-479): 4.6e-147: 430: 42.25		TCPA_HUMAN (5-533): 0: 541: 34.30
+	Hs
		821449 KS6B2_HUMAN (129-479): 4.6e-147: 430: 42.25		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Hs
		573486 SGK2_HUMAN (122-475): 1.02e-147: 428: 47.75		TCPA_HUMAN (5-533): 0: 541: 34.30
+	Hs
		821419 SGK2_HUMAN (122-475): 1.02e-147: 428: 47.75		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Hs
		568585 KAPCA_HUMAN (138-445): 1.76e-144: 419: 42.53		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Hs
		821353 SGK3_HUMAN (149-447): 5.26e-100: 310: 51.00		TCPE_HUMAN (1-528): 0: 541: 32.29
+	Dm
		520038 AKT1_DROME (3-474): 0: 523: 60.37		TCPA_DROME (1-528): 7.49e-82: 267: 34.55