HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: MAD1 (Q05195)
Max dimerization protein 1 (Max dimerizer 1) (Protein MAD)
Gene: MXD1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	19526459, 18451027
Identification Methods	affinity chromatography technology, pull down, enzymatic study, protein kinase assay
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 221
+	Hs
		346044 AKT1_HUMAN (1-480): 0: 586: 100.00		MYC_HUMAN (39-139): 6.1e-32: 122: 22.77
+	Hs
		616700 KS6B1_HUMAN (132-479): 4.01e-147: 432: 43.75		MAD1_HUMAN (1-221): 1.6e-77: 233: 100.00
+	Hs
		616687 KS6B1_HUMAN (132-479): 4.01e-147: 432: 43.75		MXI1_HUMAN (7-207): 1.24e-66: 206: 58.53
+	Hs
		345858 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		MYC_HUMAN (39-139): 6.1e-32: 122: 22.77
+	Hs
		983430 KS6A1_HUMAN (85-407): 6.15e-92: 296: 26.39		MAD1_HUMAN (1-221): 1.6e-77: 233: 100.00