HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: PDK1 (Q15118)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 1) (PDH kinase 1)
Gene: PDK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.705

Property	Details
Experiments	27166089, 34278744, 9512493, 27505672
Identification Methods	affinity chromatography technology, enzymatic study, pull down, protein kinase assay
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0004672 - protein kinase activity GO:0005524 - ATP binding GO:0005739 - mitochondrion GO:0006006 - glucose metabolic process GO:0008283 - cell population proliferation and 1 others more... GO:0016310 - phosphorylation
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 436
+	Hs
		682176 AKT2_HUMAN (1-477): 0: 559: 81.21		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Rn
		932095 KS6B1_RAT (132-479): 4.33e-147: 432: 43.75		PDK1_RAT (1-436): 0: 684: 92.20
+	Hs
		408617 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		616710 KS6B1_HUMAN (132-479): 4.01e-147: 432: 43.75		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		117006 SGK1_HUMAN (104-478): 5.29e-146: 426: 44.97		PDK1_HUMAN (1-436): 0: 674: 100.00
+	Hs
		1068035 SGK3_HUMAN (149-447): 5.26e-100: 310: 51.00		PDK1_HUMAN (1-436): 0: 674: 100.00