HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	17510053, 36736316
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 480 Hs			1 126
+	Mm
		682111 AKT1_MOUSE (1-480): 0: 587: 98.33		H2B2B_MOUSE (1-126): 2.34e-54: 168: 97.62
+	Hs
		617926 AKT1_HUMAN (1-480): 0: 586: 100.00		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Mm
		682113 AKT1_MOUSE (1-480): 0: 587: 98.33		H2B1C_MOUSE (1-126): 1.18e-53: 166: 99.21
+	Hs
		420806 AKT1_HUMAN (1-480): 0: 586: 100.00		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		681686 AKT1_HUMAN (1-480): 0: 586: 100.00		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		681937 AKT1_HUMAN (1-480): 0: 586: 100.00		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		617927 AKT2_HUMAN (1-477): 0: 559: 81.21		H2B1O_HUMAN (1-126): 3.25e-54: 167: 99.21
+	Hs
		420807 AKT2_HUMAN (1-477): 0: 559: 81.21		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		682181 AKT2_HUMAN (1-477): 0: 559: 81.21		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		682137 AKT2_HUMAN (1-477): 0: 559: 81.21		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		682194 AKT2_HUMAN (1-477): 0: 559: 81.21		H2B3B_HUMAN (1-126): 1.01e-51: 161: 96.03
+	Hs
		408525 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		H2B1J_HUMAN (1-126): 7.8e-54: 166: 99.21
+	Hs
		408583 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		H2BFS_HUMAN (1-126): 1.26e-53: 166: 96.83
+	Hs
		408591 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		408624 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		408666 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		H2B1M_HUMAN (1-126): 5.38e-54: 166: 96.03
+	Hs
		241418 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		408565 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		408585 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		H2B1D_HUMAN (1-126): 3.5e-53: 164: 98.41
+	Hs
		408664 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		H2B1N_HUMAN (1-126): 3.35e-53: 164: 98.41