HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: DAB2P (Q5VWQ8)
Disabled homolog 2-interacting protein (DAB2 interaction protein) (DAB2-interacting protein) (ASK-interacting protein 1) (AIP-1) (DOC-2/DAB-2 interactive protein)
Gene: DAB2IP

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

The method score is based on:

Property	Details
Experiments	19903888, 24912918
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0019901 - protein kinase binding and 8 others more... GO:0035556 - intracellular signal transduction GO:0035924 - cellular response to vascular endothelial growth factor stimulus GO:0042803 - protein homodimerization activity GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0071356 - cellular response to tumor necrosis factor GO:0071364 - cellular response to epidermal growth factor stimulus GO:0071889 - 14-3-3 protein binding GO:0071901 - negative regulation of protein serine/threonine kinase activity
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1	480
Hs

1	1189

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024