HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: PHLP2 (Q6ZVD8)
PH domain leucine-rich repeat-containing protein phosphatase 2 (EC 3.1.3.16) (PH domain leucine-rich repeat-containing protein phosphatase-like) (PHLPP-like)
Gene: PHLPP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.812

Property	Details
Experiments	24670654, 17386267
Identification Methods	anti tag coimmunoprecipitation, phosphatase assay
Interaction Type	physical association, dephosphorylation reaction, association

Property	Details
Interacting Pfam domains	LRR_6~Pkinase, PP2C~Pkinase
Common GO terms	GO:0005654 - nucleoplasm GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 1323
+	Rn
		88885 AKT1_RAT (1-480): 0: 588: 98.13		D4A254_RAT (1-1323): 0: 977: 92.60
+	Hs
		682190 AKT2_HUMAN (1-477): 0: 559: 81.21		PHLP2_HUMAN (1-1323): 0: 993: 100.00
+	Hs
		1172970 AKT3_HUMAN (1-478): 0: 556: 82.50		PHLP2_HUMAN (1-1323): 0: 993: 100.00
+	Hs
		408635 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		PHLP2_HUMAN (1-1323): 0: 993: 100.00
+	Hs
		232791 AKT1_HUMAN (1-480): 0: 586: 100.00		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		616717 KS6B1_HUMAN (132-479): 4.01e-147: 432: 43.75		PHLP2_HUMAN (1-1323): 0: 993: 100.00
+	Hs
		232792 AKT2_HUMAN (1-477): 0: 559: 81.21		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		233019 AKT3_HUMAN (1-478): 0: 556: 82.50		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		232762 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		232782 KS6B1_HUMAN (132-479): 4.01e-147: 432: 43.75		PHLP1_HUMAN (36-1300): 0: 845: 53.04
+	Hs
		566388 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		SCRIB_HUMAN (438-732): 2.62e-12: 73.9: 29.00
+	Hs
		850651 KS6A3_HUMAN (36-455): 4.1e-103: 325: 23.01		SCRIB_HUMAN (438-732): 2.62e-12: 73.9: 29.00
+	Hs
		784073 KPCI_HUMAN (139-474): 7.46e-101: 316: 45.53		ERBIN_HUMAN (461-746): 7.29e-10: 65.9: 24.75
+	Hs
		1049957 KS6A2_HUMAN (85-452): 6.82e-94: 301: 25.39		SCRIB_HUMAN (438-732): 2.62e-12: 73.9: 29.00
+	Hs
		1049960 KS6A1_HUMAN (85-407): 6.15e-92: 296: 26.39		SCRIB_HUMAN (438-732): 2.62e-12: 73.9: 29.00
+	Hs
		1073471 KS6A1_HUMAN (85-407): 6.15e-92: 296: 26.39		ERBIN_HUMAN (461-746): 7.29e-10: 65.9: 24.75