HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: PICK1 (Q9NRD5)
PRKCA-binding protein (Protein interacting with C kinase 1) (Protein kinase C-alpha-binding protein)
Gene: PICK1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	25640309
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0006468 - protein phosphorylation GO:0036294 - cellular response to decreased oxygen levels
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 415
+	Hs
		682214 AKT2_HUMAN (1-477): 0: 559: 81.21		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Rn
		404392 KPCA_RAT (14-477): 1.16e-151: 449: 36.27		PICK1_RAT (1-415): 0: 597: 96.39
+	Hs
		566488 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Mm
		593486 KPCA_MOUSE (14-477): 6.01e-151: 447: 36.05		PICK1_MOUSE (1-415): 0: 584: 94.47
+	Hs
		610783 KAPCB_HUMAN (138-445): 1.1e-143: 417: 42.86		PICK1_HUMAN (1-415): 0: 592: 100.00
+	Hs
		681753 AKT1_HUMAN (1-480): 0: 586: 100.00		ARFP2_HUMAN (159-354): 9.21e-57: 191: 22.45