HitPredict

Interactor 1: AKT1 (P31750)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (AKT1 kinase) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha) (Thymoma viral proto-oncogene)
Gene: AKT1

Interactor 2: PEPL (Q9R269)
Periplakin
Gene: Ppl

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	0.60	0.457

Property	Details
Experiments	15102471
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 480 Mm			1 1755
+	Hs
		234193 AKT1_HUMAN (1-480): 0: 598: 98.33		PEPL_HUMAN (1-1755): 1.42e-118: 416: 87.93
+	Hs
		681696 AKT1_HUMAN (1-480): 0: 598: 98.33		MYH9_HUMAN (905-1668): 9.92e-19: 95.8: 13.47
+	Hs
		551616 AKT1_HUMAN (1-480): 0: 598: 98.33		DESP_HUMAN (1618-1752): 4.93e-12: 73.8: 32.35
+	Hs
		623875 KPCL_HUMAN (48-477): 5.32e-156: 460: 37.04		PLEC_HUMAN (2-1224): 1.07e-36: 154: 9.35
+	Mm
		554901 KPCE_MOUSE (53-474): 3.48e-148: 442: 40.00		MYH6_MOUSE (3-770): 1.29e-24: 114: 9.63
+	Hs
		724784 KPCE_HUMAN (69-474): 1.86e-148: 443: 41.08		MYH9_HUMAN (905-1668): 9.92e-19: 95.8: 13.47
+	Hs
		551672 KPCE_HUMAN (69-474): 1.86e-148: 443: 41.08		DESP_HUMAN (1618-1752): 4.93e-12: 73.8: 32.35
+	Hs
		116964 SGK1_HUMAN (101-477): 3.86e-152: 441: 46.05		MYH1_HUMAN (2-429): 2.28e-12: 74.9: 8.47
+	Mm
		554927 KPCE_MOUSE (53-474): 3.48e-148: 442: 40.00		MYH7_MOUSE (7-434): 4.03e-11: 70.6: 10.98
+	Hs
		984550 KPCD_HUMAN (17-477): 3.11e-150: 445: 32.69		MACF1_HUMAN (453-1665): 9.39e-10: 66.4: 12.59
+	Hs
		518859 KPCZ_HUMAN (12-477): 8.22e-146: 431: 33.40		TPR_HUMAN (1-425): 5.05e-11: 70.2: 11.86
+	Hs
		1071717 KS6A2_HUMAN (37-452): 6.21e-101: 320: 23.67		MACF1_HUMAN (453-1665): 9.39e-10: 66.4: 12.59