HitPredict

Interactor 1: IL2RG (P31785)
Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)
Gene: IL2RG

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005768 - endosome GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 369 Hs			1 217
+	Mm
		872621 EPHB2_MOUSE (24-348): 1.41e-49: 180: 11.36		GRB2_MOUSE (1-217): 2.48e-76: 230: 99.54
+	Hs
		665574 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		872610 EPHB1_HUMAN (25-348): 1.08e-46: 172: 11.40		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		924590 EPHA7_HUMAN (34-348): 3.58e-45: 168: 10.98		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		500956 GHR_HUMAN (48-294): 1.74e-45: 166: 14.96		GRB2_HUMAN (1-217): 6.71e-76: 229: 100.00
+	Hs
		337360 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		ABL1_HUMAN (4-139): 4.39e-22: 95.5: 35.46
+	Hs
		665558 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Mm
		872619 EPHB2_MOUSE (24-348): 1.41e-49: 180: 11.36		ABL2_MOUSE (4-139): 1.55e-20: 91.3: 33.33
+	Hs
		557644 EPHB1_HUMAN (25-348): 1.08e-46: 172: 11.40		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		789068 EPHA7_HUMAN (34-348): 3.58e-45: 168: 10.98		ABL2_HUMAN (4-139): 9.61e-22: 94.7: 34.04
+	Hs
		500941 GHR_HUMAN (48-294): 1.74e-45: 166: 14.96		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		557643 EPHA5_HUMAN (43-348): 8.3e-45: 166: 12.87		NCK1_HUMAN (5-145): 9.45e-23: 96.3: 33.14
+	Hs
		433265 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		YES_HUMAN (59-215): 4.17e-13: 69.2: 14.91
+	Hs
		665608 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		ITSN1_HUMAN (137-216): 1.36e-12: 68.1: 25.00
+	Mm
		403425 EPHB2_MOUSE (24-348): 1.41e-49: 180: 11.36		SRC_MOUSE (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		522803 EPHB2_HUMAN (24-348): 4.44e-49: 179: 12.39		SRC_HUMAN (161-215): 3.76e-11: 63.8: 31.58
+	Hs
		548629 PRLR_HUMAN (51-294): 8.34e-46: 167: 16.28		VAV_HUMAN (2-60): 8.95e-15: 74.6: 42.37
+	Hs
		412104 EPHA5_HUMAN (43-348): 8.3e-45: 166: 12.87		FYN_HUMAN (161-215): 4.44e-14: 72.3: 31.58
+	Hs
		433772 EPHA7_HUMAN (34-348): 3.58e-45: 168: 10.98		LYN_HUMAN (129-215): 1.44e-11: 65: 22.47
+	Hs
		560471 PRLR_HUMAN (51-294): 8.34e-46: 167: 16.28		VAV2_HUMAN (3-56): 4.83e-11: 63.5: 38.18