HitPredict

Interactor 1: HECA2 (A8MVW5)
HEPACAM family member 2 (Mitotic kinetics regulator)
Gene: HEPACAM2

Interactor 2: CADM4 (Q8NFZ8)
Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2)
Gene: CADM4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.80	0.770

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	C2-set_2~Ig_3, Ig_3~Ig_3, Ig_3~V-set
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 462 Hs			1 388
+	Hs
		1108793 CEA21_HUMAN (89-237): 1.08e-42: 154: 28.86		CADM4_HUMAN (1-388): 1.56e-92: 284: 100.00
+	Hs
		530171 NCAM1_HUMAN (22-461): 3.28e-61: 215: 15.18		OPCM_HUMAN (8-340): 3.14e-56: 189: 22.09
+	Mm
		530200 NCAM1_MOUSE (22-461): 2.22e-61: 218: 14.19		NCAM1_MOUSE (15-381): 4.64e-46: 171: 15.04
+	Ce
		103933 SAX3_CAEEL (4-457): 2.08e-45: 171: 12.16		SAX3_CAEEL (25-387): 4.45e-50: 183: 16.36
+	Mm
		530206 CNTN2_MOUSE (3-439): 1.27e-39: 154: 13.00		NCAM1_MOUSE (15-381): 4.64e-46: 171: 15.04
+	Dm
		219801 O44924_DROME (140-461): 6.02e-56: 202: 17.54		O44924_DROME (16-238): 1.22e-24: 108: 14.41
+	Mm
		530211 PTK7_MOUSE (150-422): 4.03e-29: 123: 16.25		NCAM1_MOUSE (15-381): 4.64e-46: 171: 15.04
+	Hs
		1034826 NEGR1_HUMAN (160-362): 1.01e-12: 71: 15.42		LSAMP_HUMAN (29-326): 7.29e-66: 214: 22.55
+	Hs
		609294 FGFR3_HUMAN (14-437): 1.57e-59: 210: 13.78		NECT1_HUMAN (54-329): 1.32e-12: 70.9: 28.71
+	Hs
		609252 FGFR3_HUMAN (14-437): 1.57e-59: 210: 13.78		PGBM_HUMAN (89-314): 1.65e-09: 62: 23.89
+	Hs
		1378225 ROBO1_HUMAN (3-462): 2.87e-42: 162: 13.11		ROBO1_HUMAN (219-386): 6.14e-15: 78.8: 18.13
+	Rn
		222935 DCC_RAT (2-461): 1.68e-41: 160: 13.67		ROBO1_RAT (219-386): 6.66e-15: 78.8: 18.13
+	Hs
		1336275 ROBO1_HUMAN (3-462): 2.87e-42: 162: 13.11		ROBO2_HUMAN (21-264): 2.59e-13: 73.8: 16.22
+	Hs
		299578 LRIG2_HUMAN (142-435): 2.6e-41: 159: 18.47		LRIG1_HUMAN (17-117): 4.95e-13: 72.7: 11.88
+	Mm
		1149039 CNTN4_MOUSE (147-462): 2.93e-43: 165: 15.07		CNTN4_MOUSE (19-154): 5.39e-10: 63.4: 12.32
+	Hs
		1166661 LRIG1_HUMAN (121-434): 1.8e-39: 154: 13.51		LRIG3_HUMAN (17-134): 1.02e-09: 62.3: 11.02
+	Hs
		1336269 ROBO2_HUMAN (235-462): 2.47e-28: 120: 13.88		ROBO2_HUMAN (21-264): 2.59e-13: 73.8: 16.22
+	Dm
		590089 NRG_DROME (2-459): 4.55e-28: 120: 10.62		Q9VQW7_DROME (120-295): 1.67e-09: 61.6: 28.65