Interactor 1: MP2K1 (P31938)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: Map2k1

Interactor 2: KSR1 (Q61097)
Kinase suppressor of Ras 1 (mKSR1) (EC 2.7.11.1) (Protein Hb)
Gene: KSR1

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.91 1.00 0.959

The method score is based on:

Property Details
Experiments 18332145, 21144847, 15520859, 12932319, 17174095, 15121859, 17613518
Identification Methods affinity chromatography technology, enzymatic study, anti tag coimmunoprecipitation
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~Pkinase
Common GO terms GO:0004674 - protein serine/threonine kinase activity
GO:0005078 - MAP-kinase scaffold activity
GO:0005524 - ATP binding
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
and 4 others

more...

Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 393
Mm

1 873
+ Mm
+ Rn
+ Hs
+ Hs
+ Hs
+ Gg
+ Hs
+ Hs
+ Mm
+ Dm
+ Dm
+ Hs
+ Mm
+ Mm
+ Mm
+ Hs
+ Dm
+ Ce
+ Ce
+ Ce

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024