HitPredict

Interactor 1: HNRH1 (P31943)
Heterogeneous nuclear ribonucleoprotein H (hnRNP H) [Cleaved into: Heterogeneous nuclear ribonucleoprotein H, N-terminally processed]
Gene: HNRNPH1

Interactor 2: TADBP (Q13148)
TAR DNA-binding protein 43 (TDP-43)
Gene: TARDBP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	1.00	0.830

Property	Details
Experiments	20020773, 32814053, 29725819
Identification Methods	affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1, RRM_1~zf-RNPHF
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 449 Hs			1 414
+	Hs
		1025728 PABP4_HUMAN (1-447): 8.75e-85: 274: 13.92		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		516491 PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70		TADBP_HUMAN (1-414): 4.24e-84: 264: 100.00
+	Hs
		162035 PABP4_HUMAN (1-447): 8.75e-85: 274: 13.92		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		161948 PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Mm
		193450 HNRH1_MOUSE (1-449): 1.88e-75: 244: 99.78		TADBP_MOUSE (1-414): 1.47e-79: 253: 96.14
+	Hs
		516424 PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		161970 HNRH1_HUMAN (1-449): 1.86e-75: 244: 100.00		HNRDL_HUMAN (62-376): 5.62e-71: 231: 23.60
+	Hs
		682738 HNRH1_HUMAN (1-449): 1.86e-75: 244: 100.00		ROA3_HUMAN (98-269): 2.33e-69: 225: 28.57
+	Hs
		474021 PABP4_HUMAN (1-447): 8.75e-85: 274: 13.92		PAB4L_HUMAN (2-276): 8.18e-56: 189: 16.96
+	Mm
		665745 PABP1_MOUSE (1-446): 3.46e-84: 272: 13.70		TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92
+	Hs
		516495 PABP4_HUMAN (1-447): 8.75e-85: 274: 13.92		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		516339 PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70		PABP1_HUMAN (2-382): 7.78e-31: 126: 15.95
+	Hs
		516689 PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70		PABP3_HUMAN (2-382): 7.84e-31: 126: 16.41
+	Mm
		193432 HNRH1_MOUSE (1-449): 1.88e-75: 244: 99.78		TIA1_MOUSE (99-413): 1.08e-36: 139: 12.92
+	Hs
		516511 PABP1_HUMAN (1-446): 2.77e-84: 272: 13.70		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Zm
		8143 A0A1D6ELH4_MAIZE (9-440): 1.34e-72: 242: 13.27		A0A1D6ELH4_MAIZE (74-268): 1.5e-29: 122: 17.24
+	Hs
		682807 HNRH1_HUMAN (1-449): 1.86e-75: 244: 100.00		HNRPD_HUMAN (81-238): 5.59e-21: 95.1: 35.93
+	Hs
		682930 HNRH1_HUMAN (1-449): 1.86e-75: 244: 100.00		MSI2H_HUMAN (41-207): 5.16e-20: 92.2: 23.81