HitPredict

Interactor 1: CASPE (P31944)
Caspase-14 (CASP-14) (EC 3.4.22.-) [Cleaved into: Caspase-14 subunit p17, mature form; Caspase-14 subunit p10, mature form; Caspase-14 subunit p20, intermediate form; Caspase-14 subunit p8, intermediate form]
Gene: CASP14

Interactor 2: NALP7 (Q8WX94)
NACHT, LRR and PYD domains-containing protein 7 (Nucleotide-binding oligomerization domain protein 12) (PYRIN-containing APAF1-like protein 3)
Gene: NLRP7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	33838681
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 242 Hs			1 980
+	Hs
		667480 CASP1_HUMAN (6-241): 3.79e-86: 262: 24.71		NALP7_HUMAN (1-980): 0: 758: 100.00
+	Hs
		667478 CASP1_HUMAN (6-241): 3.79e-86: 262: 24.71		NAL10_HUMAN (1-584): 1.26e-150: 462: 28.24
+	Mm
		667124 CASP1_MOUSE (3-241): 1.01e-86: 264: 23.74		NLRC4_MOUSE (135-974): 4.81e-82: 289: 15.59
+	Hs
		667491 CASP1_HUMAN (6-241): 3.79e-86: 262: 24.71		NLRC4_HUMAN (135-974): 9e-82: 288: 15.21
+	Hs
		1059374 CASP8_HUMAN (12-241): 7.41e-80: 249: 29.58		NLRC4_HUMAN (135-974): 9e-82: 288: 15.21
+	Hs
		667484 CASP1_HUMAN (6-241): 3.79e-86: 262: 24.71		NLRP3_HUMAN (566-908): 1.97e-41: 167: 25.58
+	Mm
		667128 CASP1_MOUSE (3-241): 1.01e-86: 264: 23.74		NLRP3_MOUSE (825-980): 8.44e-24: 110: 32.48
+	Hs
		667448 CASP1_HUMAN (6-241): 3.79e-86: 262: 24.71		NLRP6_HUMAN (800-974): 3.07e-19: 95.5: 32.77
+	Mm
		667127 CASP1_MOUSE (3-241): 1.01e-86: 264: 23.74		NOD2_MOUSE (765-979): 3.87e-18: 92: 20.47
+	Hs
		830296 CASP4_HUMAN (5-241): 1.44e-87: 265: 23.83		NOD2_HUMAN (560-817): 6.59e-17: 88.2: 15.47
+	Hs
		667493 CASP1_HUMAN (6-241): 3.79e-86: 262: 24.71		NALP2_HUMAN (778-980): 3.83e-17: 88.9: 27.32
+	Hs
		667490 CASP1_HUMAN (6-241): 3.79e-86: 262: 24.71		NOD2_HUMAN (560-817): 6.59e-17: 88.2: 15.47
+	Hs
		830305 CASP4_HUMAN (5-241): 1.44e-87: 265: 23.83		NOD1_HUMAN (765-979): 1.36e-15: 83.9: 20.93
+	Hs
		667501 CASP1_HUMAN (6-241): 3.79e-86: 262: 24.71		NOD1_HUMAN (765-979): 1.36e-15: 83.9: 20.93
+	Hs
		1059401 CASP8_HUMAN (12-241): 7.41e-80: 249: 29.58		NOD1_HUMAN (765-979): 1.36e-15: 83.9: 20.93
+	Hs
		851077 CASP5_HUMAN (3-241): 1.05e-86: 265: 25.58		NLRP1_HUMAN (871-980): 3.06e-09: 63.5: 24.32
+	Hs
		667487 CASP1_HUMAN (6-241): 3.79e-86: 262: 24.71		NLRP1_HUMAN (871-980): 3.06e-09: 63.5: 24.32
+	Hs
		788267 CASP2_HUMAN (16-241): 5.86e-77: 241: 29.20		NOD1_HUMAN (765-979): 1.36e-15: 83.9: 20.93
+	Hs
		876977 CASP9_HUMAN (13-242): 8.85e-77: 239: 26.12		BIRC1_HUMAN (531-882): 1.29e-13: 77.8: 13.48
+	Hs
		788263 CASP2_HUMAN (16-241): 5.86e-77: 241: 29.20		NLRP1_HUMAN (871-980): 3.06e-09: 63.5: 24.32