HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: MTOR (P42345)
Serine/threonine-protein kinase mTOR (EC 2.7.11.1) (FK506-binding protein 12-rapamycin complex-associated protein 1) (FKBP12-rapamycin complex-associated protein) (Mammalian target of rapamycin) (mTOR) (Mechanistic target of rapamycin) (Rapamycin and FKBP12 target 1) (Rapamycin target protein 1)
Gene: MTOR

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	35271311, 36931259
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0016020 - membrane GO:0051219 - phosphoprotein binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 2549
+	Hs
		787440 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		787451 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		646705 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		787438 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		787460 1433F_HUMAN (4-244): 2.7e-107: 311: 75.51		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		683882 1433S_HUMAN (3-239): 3.38e-100: 293: 68.62		MTOR_HUMAN (1-2549): 0: 2102: 100.00
+	Hs
		927004 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		ATM_HUMAN (387-2548): 0: 894: 14.98
+	Hs
		683847 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		TRRAP_HUMAN (925-2548): 0: 720: 15.53
+	At
		788647 14333_ARATH (3-241): 4.44e-143: 402: 62.96		ATM_ARATH (401-2548): 0: 704: 13.98
+	Hs
		683261 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Hs
		926917 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Hs
		646792 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Hs
		905297 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		TRRAP_HUMAN (925-2548): 0: 720: 15.53
+	Hs
		904439 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		PRKDC_HUMAN (695-2548): 0: 686: 14.83
+	Hs
		904645 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12
+	Hs
		982077 1433F_HUMAN (4-244): 2.7e-107: 311: 75.51		Q4LE69_HUMAN (733-2453): 1.63e-160: 553: 12.12
+	Hs
		927364 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17
+	Hs
		647159 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		GCN1_HUMAN (245-1372): 1.05e-38: 162: 12.17
+	Dm
		664613 1433Z_DROME (2-246): 4.79e-141: 396: 78.78		Q7K3H0_DROME (1898-2419): 8.48e-26: 119: 19.33