HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: MP2K6 (P52564)
Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)
Gene: MAP2K6

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 334
+	Hs
		681770 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AKT1_HUMAN (12-334): 4.87e-124: 366: 22.05
+	Hs
		909730 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK2_HUMAN (6-331): 1.06e-118: 362: 20.30
+	Mm
		910234 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK2_MOUSE (6-331): 2.33e-118: 360: 20.30
+	Hs
		647862 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK3_HUMAN (3-330): 2.94e-118: 359: 19.21
+	Hs
		647835 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		MARK3_HUMAN (3-330): 2.94e-118: 359: 19.21
+	Mm
		910231 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK3_MOUSE (3-330): 1.86e-117: 357: 19.21
+	Hs
		909916 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK4_HUMAN (4-330): 9.87e-117: 355: 21.28
+	Mm
		910308 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK4_MOUSE (4-330): 9.26e-117: 355: 21.28
+	Hs
		625306 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK2_HUMAN (50-325): 6.07e-120: 348: 24.09
+	At
		965360 14332_ARATH (1-241): 4.75e-145: 407: 63.27		CIPKC_ARATH (19-317): 8.07e-113: 337: 22.62
+	At
		1280891 14337_ARATH (1-239): 1.25e-144: 406: 61.73		CIPKC_ARATH (19-317): 8.07e-113: 337: 22.62
+	Hs
		153111 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MP2K7_HUMAN (4-333): 2.81e-108: 323: 41.84
+	Hs
		909502 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		STK4_HUMAN (20-324): 2.53e-103: 313: 33.88
+	Hs
		909512 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		STK3_HUMAN (24-315): 1.2e-101: 309: 33.67
+	Hs
		131551 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		STK25_HUMAN (41-328): 1.48e-96: 293: 30.00
+	Hs
		909461 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MP2K1_HUMAN (47-333): 9.74e-67: 216: 37.69
+	Hs
		683280 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		MP2K1_HUMAN (47-333): 9.74e-67: 216: 37.69
+	Hs
		734905 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MP2K2_HUMAN (47-328): 1.9e-64: 210: 36.89
+	Hs
		683173 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		MP2K2_HUMAN (47-328): 1.9e-64: 210: 36.89
+	Dm
		954998 1433E_DROME (3-245): 4.63e-144: 405: 64.90		DSOR1_DROME (47-328): 2.4e-62: 205: 38.96