HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: GEM (P55040)
GTP-binding protein GEM (GTP-binding mitogen-induced T-cell protein) (RAS-like protein KIR)
Gene: GEM

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.612

Property	Details
Experiments	30833792, 14701738
Identification Methods	affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007165 - signal transduction
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 296
+	Hs
		874260 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		GEM_HUMAN (1-296): 6.84e-96: 286: 100.00
+	Hs
		874262 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		GEM_HUMAN (1-296): 6.84e-96: 286: 100.00
+	Mm
		874362 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		GEM_MOUSE (1-296): 1.16e-93: 280: 95.61
+	Mm
		292073 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		RAD_MOUSE (14-296): 2.52e-90: 272: 56.54
+	Hs
		874364 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		RAD_HUMAN (9-296): 4.96e-86: 261: 55.86
+	Hs
		271818 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		REM1_HUMAN (1-296): 7.83e-83: 253: 47.35
+	Mm
		193598 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		REM1_MOUSE (1-296): 3.12e-84: 256: 46.36
+	Hs
		271819 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		REM1_HUMAN (1-296): 7.83e-83: 253: 47.35
+	Hs
		646749 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		GEM_HUMAN (1-296): 6.84e-96: 286: 100.00
+	Hs
		909599 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RB11B_HUMAN (66-293): 9.58e-80: 242: 26.09
+	Hs
		927083 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		RB11B_HUMAN (66-293): 9.58e-80: 242: 26.09
+	Mm
		926856 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		REM2_MOUSE (76-296): 2.24e-70: 223: 51.09
+	Hs
		271817 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		REM1_HUMAN (1-296): 7.83e-83: 253: 47.35
+	Hs
		874258 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		GEM_HUMAN (1-296): 6.84e-96: 286: 100.00
+	Hs
		271820 1433F_HUMAN (4-244): 2.7e-107: 311: 75.51		REM1_HUMAN (1-296): 7.83e-83: 253: 47.35
+	Hs
		904422 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		RB11A_HUMAN (66-293): 3.37e-80: 243: 26.09
+	Hs
		904607 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		RB11B_HUMAN (66-293): 9.58e-80: 242: 26.09
+	Hs
		919617 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		RAP1A_HUMAN (76-239): 4.07e-22: 92.8: 35.93