HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: KPCD (Q05655)
Protein kinase C delta type (EC 2.7.11.13) (Tyrosine-protein kinase PRKCD) (EC 2.7.10.2) (nPKC-delta) [Cleaved into: Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunit (Sphingosine-dependent protein kinase-1) (SDK1)]
Gene: PRKCD

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	16024783
Identification Methods	in-gel kinase assay
Interaction Type	phosphorylation reaction

Property	Details
Interacting Pfam domains	14-3-3~C1_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0019899 - enzyme binding GO:0048471 - perinuclear region of cytoplasm and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 676
+	Hs
		926957 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KPCD_HUMAN (1-676): 0: 790: 100.00
+	Hs
		646820 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		KPCT_HUMAN (1-674): 0: 732: 62.13
+	Hs
		909458 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KPCE_HUMAN (16-665): 0: 680: 40.23
+	Hs
		683276 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KPCE_HUMAN (16-665): 0: 680: 40.23
+	Hs
		926942 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KPCE_HUMAN (16-665): 0: 680: 40.23
+	Mm
		554936 1433B_MOUSE (1-246): 5.56e-141: 396: 98.78		KPCE_MOUSE (16-665): 0: 678: 40.65
+	Hs
		646812 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		KPCE_HUMAN (16-665): 0: 680: 40.23
+	Hs
		681770 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AKT1_HUMAN (270-667): 1.98e-150: 446: 36.86
+	Hs
		681776 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		AKT1_HUMAN (270-667): 1.98e-150: 446: 36.86
+	Hs
		397155 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KPCG_HUMAN (129-355): 1.07e-42: 166: 29.75
+	Hs
		566348 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KPCA_HUMAN (128-353): 1.03e-42: 166: 31.20
+	Hs
		783970 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KPCI_HUMAN (59-270): 2.75e-35: 143: 19.54
+	Hs
		683182 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KPCI_HUMAN (59-270): 2.75e-35: 143: 19.54
+	Hs
		683286 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KPCZ_HUMAN (66-231): 1.99e-35: 143: 19.19
+	Hs
		783973 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KPCI_HUMAN (59-270): 2.75e-35: 143: 19.54
+	Hs
		926956 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KPCZ_HUMAN (66-231): 1.99e-35: 143: 19.19
+	Hs
		566293 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		KPCA_HUMAN (128-353): 1.03e-42: 166: 31.20
+	Hs
		646701 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		KPCI_HUMAN (59-270): 2.75e-35: 143: 19.54
+	Hs
		646824 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		KPCZ_HUMAN (66-231): 1.99e-35: 143: 19.19
+	Hs
		397154 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		KPCG_HUMAN (129-355): 1.07e-42: 166: 29.75