HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: AAPK1 (Q13131)
5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Gene: PRKAA1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36736316
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 559
+	Hs
		909507 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AAPK1_HUMAN (1-559): 0: 595: 100.00
+	Rn
		871214 1433E_RAT (3-243): 4.39e-144: 405: 65.43		AAPK1_RAT (1-559): 0: 593: 99.11
+	Hs
		871354 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AAPK2_HUMAN (13-559): 0: 535: 75.41
+	Hs
		683222 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		AAPK2_HUMAN (13-559): 0: 535: 75.41
+	Hs
		909730 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK2_HUMAN (10-545): 5.04e-150: 451: 29.64
+	Hs
		683485 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		MARK2_HUMAN (10-545): 5.04e-150: 451: 29.64
+	Mm
		910234 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK2_MOUSE (3-545): 1.66e-148: 447: 29.08
+	Hs
		647862 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK3_HUMAN (3-543): 7.31e-144: 434: 28.21
+	Hs
		647835 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		MARK3_HUMAN (3-543): 7.31e-144: 434: 28.21
+	At
		965360 14332_ARATH (1-241): 4.75e-145: 407: 63.27		CIPKC_ARATH (8-530): 5.91e-146: 431: 25.48
+	At
		1280891 14337_ARATH (1-239): 1.25e-144: 406: 61.73		CIPKC_ARATH (8-530): 5.91e-146: 431: 25.48
+	Mm
		910231 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK3_MOUSE (11-543): 4.46e-143: 432: 28.31
+	Hs
		883214 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SIK1_HUMAN (4-401): 2.75e-142: 431: 38.21
+	Hs
		683233 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SIK1_HUMAN (4-401): 2.75e-142: 431: 38.21
+	Hs
		909916 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK4_HUMAN (18-543): 9.01e-140: 424: 28.76
+	Mm
		910308 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK4_MOUSE (11-404): 2.19e-133: 407: 35.56
+	Hs
		910013 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SIK2_HUMAN (10-340): 1.75e-85: 286: 42.69
+	Hs
		909786 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		BRSK2_HUMAN (24-376): 3.25e-82: 273: 42.12
+	Mm
		910272 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		BRSK2_MOUSE (24-376): 4.35e-82: 273: 42.12
+	Mm
		910248 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		BRSK1_MOUSE (24-279): 1.44e-80: 270: 50.78