HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: DYR1A (Q13627)
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (EC 2.7.11.23) (EC 2.7.12.1) (Dual specificity YAK1-related kinase) (HP86) (Protein kinase minibrain homolog) (MNBH) (hMNB)
Gene: DYRK1A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.708

Property	Details
Experiments	30773093, 36931259, 17353931, 17229891, 36950384
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, pull down, anti tag coimmunoprecipitation, two hybrid
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 763
+	Hs
		909539 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYR1A_HUMAN (1-763): 0: 613: 100.00
+	Mm
		910255 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		DYR1A_MOUSE (1-763): 0: 610: 99.21
+	Hs
		910197 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYR1B_HUMAN (57-600): 2.33e-137: 421: 68.13
+	Hs
		647862 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK3_HUMAN (105-758): 1.17e-123: 389: 17.72
+	Hs
		647835 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		MARK3_HUMAN (105-758): 1.17e-123: 389: 17.72
+	Mm
		910231 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK3_MOUSE (105-758): 2.37e-123: 388: 17.87
+	Hs
		647869 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		MARK3_HUMAN (105-758): 1.17e-123: 389: 17.72
+	Mm
		926780 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		MARK3_MOUSE (105-758): 2.37e-123: 388: 17.87
+	Xl
		223344 O57468_XENLA (4-243): 2.71e-143: 402: 66.12		Q804T2_XENLA (105-761): 1.81e-121: 383: 17.49
+	Hs
		909877 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYRK2_HUMAN (46-549): 5.03e-120: 375: 33.53
+	Hs
		910066 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DYRK4_HUMAN (132-590): 2.67e-118: 367: 35.78
+	Hs
		681770 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42
+	Hs
		625306 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Hs
		909447 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CDK3_HUMAN (156-436): 1.81e-117: 358: 26.12
+	Hs
		683268 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CDK3_HUMAN (156-436): 1.81e-117: 358: 26.12
+	Hs
		681776 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		AKT1_HUMAN (38-466): 4.44e-117: 363: 19.42
+	Hs
		625334 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CDK2_HUMAN (156-420): 1.05e-117: 358: 26.85
+	Hs
		909828 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		HIPK4_HUMAN (157-478): 1.65e-53: 197: 38.30
+	At
		847169 14332_ARATH (1-241): 4.75e-145: 407: 63.27		AFC1_ARATH (141-485): 6.57e-53: 192: 32.17
+	Zm
		27099 B6SRI4_MAIZE (3-243): 3.69e-143: 402: 63.27		A0A1D6JDK3_MAIZE (136-478): 9.83e-51: 193: 33.58