HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: CRTC2 (Q53ET0)
CREB-regulated transcription coactivator 2 (Transducer of regulated cAMP response element-binding protein 2) (TORC-2) (Transducer of CREB protein 2)
Gene: CRTC2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.747

Property	Details
Experiments	33961781, 35271311, 36931259, 15324660, 24255178, 28514442, 15454081
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 693
+	Hs
		909630 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CRTC2_HUMAN (1-693): 1.02e-75: 259: 100.00
+	Hs
		927110 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CRTC2_HUMAN (1-693): 1.02e-75: 259: 100.00
+	Hs
		646948 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		CRTC2_HUMAN (1-693): 1.02e-75: 259: 100.00
+	Mm
		910268 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		CRTC1_MOUSE (14-692): 1.51e-43: 168: 34.43
+	Hs
		909699 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CRTC3_HUMAN (10-692): 3.58e-28: 122: 34.10
+	Hs
		683463 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CRTC3_HUMAN (10-692): 3.58e-28: 122: 34.10
+	Hs
		927184 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CRTC3_HUMAN (10-692): 3.58e-28: 122: 34.10
+	Hs
		909700 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CRTC1_HUMAN (14-692): 3.45e-25: 113: 31.41
+	Hs
		683464 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CRTC1_HUMAN (14-692): 3.45e-25: 113: 31.41
+	Rn
		910356 1433E_RAT (3-243): 4.39e-144: 405: 65.43		CRTC1_RAT (14-692): 2.63e-24: 109: 28.49
+	Hs
		927185 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CRTC1_HUMAN (14-692): 3.45e-25: 113: 31.41
+	Hs
		909712 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		OTOG_HUMAN (75-636): 2.31e-18: 92.6: 15.12
+	Hs
		683472 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		OTOG_HUMAN (75-636): 2.31e-18: 92.6: 15.12
+	Hs
		297821 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		K0754_HUMAN (6-347): 2.26e-17: 89.1: 12.28
+	Hs
		297815 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		K0754_HUMAN (6-347): 2.26e-17: 89.1: 12.28
+	Hs
		927196 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		OTOG_HUMAN (75-636): 2.31e-18: 92.6: 15.12
+	Hs
		297824 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		K0754_HUMAN (6-347): 2.26e-17: 89.1: 12.28
+	Hs
		909937 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CIC_HUMAN (88-691): 4e-09: 62.2: 9.81
+	Hs
		683645 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CIC_HUMAN (88-691): 4e-09: 62.2: 9.81
+	Hs
		927430 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CIC_HUMAN (88-691): 4e-09: 62.2: 9.81