HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: DLG5 (Q8TDM6)
Disks large homolog 5 (Discs large protein P-dlg) (Placenta and prostate DLG)
Gene: DLG5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	33961781, 35271311, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1919
+	Hs
		909845 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DLG5_HUMAN (1-1919): 0: 936: 100.00
+	Hs
		927332 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		DLG5_HUMAN (1-1919): 0: 936: 100.00
+	Hs
		647130 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		DLG5_HUMAN (1-1919): 0: 936: 100.00
+	Mm
		910260 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Mm
		926805 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Mm
		1143489 1433B_MOUSE (1-246): 5.56e-141: 396: 98.78		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Dm
		677686 1433E_DROME (3-245): 4.63e-144: 405: 64.90		DLG1_DROME (1123-1916): 3.18e-132: 441: 20.16
+	Dm
		664599 1433Z_DROME (2-246): 4.79e-141: 396: 78.78		DLG1_DROME (1123-1916): 3.18e-132: 441: 20.16
+	Mm
		905344 1433G_MOUSE (3-246): 1.91e-109: 317: 75.40		DLG4_MOUSE (1177-1916): 2.2e-156: 500: 20.46
+	Hs
		910124 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		683788 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		909488 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CGNL1_HUMAN (145-628): 2.87e-10: 67.8: 21.72
+	Hs
		683298 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		CGNL1_HUMAN (145-628): 2.87e-10: 67.8: 21.72
+	Hs
		927623 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		683290 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81
+	Hs
		926974 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		CGNL1_HUMAN (145-628): 2.87e-10: 67.8: 21.72
+	Hs
		926961 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81
+	Hs
		647357 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		ZO2_HUMAN (1470-1802): 2.6e-11: 71.2: 13.01
+	Hs
		646838 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		CGNL1_HUMAN (145-628): 2.87e-10: 67.8: 21.72
+	Hs
		646827 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		ZO1_HUMAN (698-816): 3.52e-09: 64.5: 16.81