HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: M3K3 (Q99759)
Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3)
Gene: MAP3K3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.727

Property	Details
Experiments	33961781, 36931259, 36736316, 14743216, 28514442, 18308725
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 626
+	Hs
		909957 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		M3K3_HUMAN (1-626): 0: 606: 100.00
+	Hs
		910191 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Hs
		683841 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		M3K2_HUMAN (1-622): 3.22e-174: 510: 64.33
+	Mm
		910275 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		DCLK2_MOUSE (21-624): 1.04e-138: 424: 16.51
+	Hs
		909811 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DCLK2_HUMAN (21-624): 3.27e-138: 422: 16.19
+	Hs
		683540 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		DCLK2_HUMAN (21-624): 3.27e-138: 422: 16.19
+	Hs
		683287 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KPCD_HUMAN (22-625): 8.67e-139: 421: 17.86
+	Hs
		166549 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DCLK1_HUMAN (21-624): 5.2e-136: 416: 16.90
+	Hs
		166539 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		DCLK1_HUMAN (21-624): 5.2e-136: 416: 16.90
+	Hs
		166550 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		DCLK1_HUMAN (21-624): 5.2e-136: 416: 16.90
+	Mm
		910345 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		DCLK1_MOUSE (21-624): 2.8e-133: 409: 16.54
+	Zm
		45993 B6SRI4_MAIZE (3-243): 3.69e-143: 402: 63.27		A0A1Q0ZG94_MAIZE (20-625): 5.87e-126: 403: 17.13
+	At
		965360 14332_ARATH (1-241): 4.75e-145: 407: 63.27		CIPKC_ARATH (342-626): 1.65e-129: 391: 25.78
+	At
		1280891 14337_ARATH (1-239): 1.25e-144: 406: 61.73		CIPKC_ARATH (342-626): 1.65e-129: 391: 25.78
+	At
		788672 14333_ARATH (3-241): 4.44e-143: 402: 62.96		CIPKC_ARATH (342-626): 1.65e-129: 391: 25.78
+	Hs
		910114 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		PAK5_HUMAN (37-624): 7.39e-124: 384: 21.13
+	Hs
		681770 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AKT1_HUMAN (247-622): 1.65e-126: 383: 21.67
+	Hs
		683779 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		PAK5_HUMAN (37-624): 7.39e-124: 384: 21.13
+	At
		788620 14333_ARATH (3-241): 4.44e-143: 402: 62.96		M3K2_ARATH (343-622): 6.39e-115: 359: 46.67
+	Hs
		909513 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		M3K1_HUMAN (362-619): 9.22e-53: 197: 44.03