HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: PAK6 (Q9NQU5)
Serine/threonine-protein kinase PAK 6 (EC 2.7.11.1) (PAK-5) (p21-activated kinase 6) (PAK-6)
Gene: PAK6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045296 - cadherin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 681
+	Hs
		910063 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		PAK6_HUMAN (1-681): 0: 641: 100.00
+	Hs
		910114 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		PAK5_HUMAN (1-676): 1.65e-174: 516: 44.51
+	Hs
		683779 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		PAK5_HUMAN (1-676): 1.65e-174: 516: 44.51
+	Hs
		330944 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		330872 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		330968 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		PAK4_HUMAN (1-675): 1.1e-156: 466: 43.79
+	Hs
		909458 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KPCE_HUMAN (263-677): 1.74e-130: 404: 20.55
+	Hs
		683276 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KPCE_HUMAN (263-677): 1.74e-130: 404: 20.55
+	At
		965360 14332_ARATH (1-241): 4.75e-145: 407: 63.27		CIPKC_ARATH (387-661): 2.36e-131: 397: 25.62
+	At
		1280891 14337_ARATH (1-239): 1.25e-144: 406: 61.73		CIPKC_ARATH (387-661): 2.36e-131: 397: 25.62
+	Hs
		681770 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AKT1_HUMAN (349-680): 1.47e-131: 398: 23.10
+	Hs
		926942 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KPCE_HUMAN (263-677): 1.74e-130: 404: 20.55
+	At
		788672 14333_ARATH (3-241): 4.44e-143: 402: 62.96		CIPKC_ARATH (387-661): 2.36e-131: 397: 25.62
+	Hs
		681776 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		AKT1_HUMAN (349-680): 1.47e-131: 398: 23.10
+	Hs
		568616 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KAPCA_HUMAN (384-680): 1.08e-129: 388: 24.44
+	Hs
		568620 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KAPCA_HUMAN (384-680): 1.08e-129: 388: 24.44
+	Hs
		909502 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		STK4_HUMAN (402-671): 1.41e-122: 375: 38.97
+	Hs
		683308 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		STK4_HUMAN (402-671): 1.41e-122: 375: 38.97
+	Hs
		909512 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		STK3_HUMAN (387-671): 3.06e-121: 372: 37.59
+	Hs
		683316 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		STK3_HUMAN (387-671): 3.06e-121: 372: 37.59