HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: DACT1 (Q9NYF0)
Dapper homolog 1 (hDPR1) (Dapper antagonist of catenin 1) (Hepatocellular carcinoma novel gene 3 protein)
Gene: DACT1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.57	0.60	0.586

Property	Details
Experiments	21262972
Identification Methods	two hybrid, affinity chromatography technology, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042826 - histone deacetylase binding
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 836
+	Hs
		910089 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DACT1_HUMAN (1-836): 0: 773: 100.00
+	Hs
		927586 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		DACT1_HUMAN (1-836): 0: 773: 100.00
+	Hs
		647324 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		DACT1_HUMAN (1-836): 0: 773: 100.00
+	Hs
		905180 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		DACT1_HUMAN (1-836): 0: 773: 100.00
+	Hs
		982550 1433F_HUMAN (4-244): 2.7e-107: 311: 75.51		DACT1_HUMAN (1-836): 0: 773: 100.00
+	Hs
		684356 1433S_HUMAN (3-239): 3.38e-100: 293: 68.62		DACT1_HUMAN (1-836): 0: 773: 100.00
+	Hs
		297821 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		K0754_HUMAN (167-637): 1.15e-27: 123: 12.16
+	Hs
		297815 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		K0754_HUMAN (167-637): 1.15e-27: 123: 12.16
+	Hs
		297824 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		K0754_HUMAN (167-637): 1.15e-27: 123: 12.16
+	Hs
		909712 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		OTOG_HUMAN (158-602): 3.41e-14: 79.4: 12.21
+	Hs
		683472 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		OTOG_HUMAN (158-602): 3.41e-14: 79.4: 12.21
+	Hs
		927196 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		OTOG_HUMAN (158-602): 3.41e-14: 79.4: 12.21
+	Hs
		647025 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		OTOG_HUMAN (158-602): 3.41e-14: 79.4: 12.21
+	Hs
		904746 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		OTOG_HUMAN (158-602): 3.41e-14: 79.4: 12.21
+	Hs
		982175 1433F_HUMAN (4-244): 2.7e-107: 311: 75.51		OTOG_HUMAN (158-602): 3.41e-14: 79.4: 12.21
+	Hs
		203217 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		SYNJ1_HUMAN (99-632): 2.1e-09: 63.6: 14.50
+	Hs
		203222 1433F_HUMAN (4-244): 2.7e-107: 311: 75.51		SYNJ1_HUMAN (99-632): 2.1e-09: 63.6: 14.50