HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: MARK1 (Q9P0L2)
Serine/threonine-protein kinase MARK1 (EC 2.7.11.1) (EC 2.7.11.26) (MAP/microtubule affinity-regulating kinase 1) (PAR1 homolog c) (Par-1c) (Par1c)
Gene: MARK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	36736316, 33961781, 35271311, 24255178, 28514442
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 795
+	Hs
		910106 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK1_HUMAN (1-795): 0: 775: 100.00
+	Mm
		910318 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK1_MOUSE (1-795): 0: 767: 94.34
+	Mm
		910234 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK2_MOUSE (2-795): 0: 672: 64.55
+	Hs
		909730 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK2_HUMAN (2-795): 0: 668: 63.76
+	Hs
		647862 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Hs
		647835 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		MARK3_HUMAN (1-795): 0: 664: 63.86
+	Mm
		910231 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK3_MOUSE (1-795): 0: 662: 62.87
+	Dm
		90534 1433E_DROME (3-245): 4.63e-144: 405: 64.90		E1JGN0_DROME (8-795): 0: 594: 48.17
+	Hs
		909916 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MARK4_HUMAN (1-795): 0: 570: 49.32
+	Mm
		910308 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		MARK4_MOUSE (1-795): 0: 569: 49.01
+	Hs
		909567 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MELK_HUMAN (56-795): 1.01e-161: 485: 25.30
+	Hs
		910013 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SIK2_HUMAN (45-766): 2.35e-142: 444: 28.27
+	Hs
		910187 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SIK3_HUMAN (36-620): 8.16e-139: 444: 36.67
+	Hs
		910071 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SNRK_HUMAN (55-794): 1.35e-143: 442: 22.91
+	Hs
		883214 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SIK1_HUMAN (38-677): 5.5e-142: 439: 31.42
+	Hs
		683233 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SIK1_HUMAN (38-677): 5.5e-142: 439: 31.42
+	Rn
		871214 1433E_RAT (3-243): 4.39e-144: 405: 65.43		AAPK1_RAT (34-579): 1.58e-142: 433: 28.29
+	Hs
		871354 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AAPK2_HUMAN (46-598): 4.07e-142: 431: 28.50
+	Hs
		909507 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		AAPK1_HUMAN (34-579): 4.11e-142: 431: 28.10
+	Hs
		683222 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		AAPK2_HUMAN (46-598): 4.07e-142: 431: 28.50