HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: SH3B4 (Q9P0V3)
SH3 domain-binding protein 4 (EH-binding protein 10) (Transferrin receptor-trafficking protein)
Gene: SH3BP4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.88	0.60	0.729

Property	Details
Experiments	33761321, 33961781, 35271311, 36931259, 17353931, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0070062 - extracellular exosome
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 963
+	Hs
		910108 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SH3B4_HUMAN (1-963): 0: 1835: 100.00
+	Hs
		927602 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		SH3B4_HUMAN (1-963): 0: 1835: 100.00
+	Mm
		910324 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		SH3B4_MOUSE (1-963): 0: 1813: 91.60
+	Mm
		926863 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		SH3B4_MOUSE (1-963): 0: 1813: 91.60
+	Mm
		1265696 1433B_MOUSE (1-246): 5.56e-141: 396: 98.78		SH3B4_MOUSE (1-963): 0: 1813: 91.60
+	Hs
		647337 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		SH3B4_HUMAN (1-963): 0: 1835: 100.00
+	Mm
		933138 1433T_MOUSE (3-244): 9.37e-127: 360: 81.82		SH3B4_MOUSE (1-963): 0: 1813: 91.60
+	Hs
		905197 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		SH3B4_HUMAN (1-963): 0: 1835: 100.00
+	Hs
		982565 1433F_HUMAN (4-244): 2.7e-107: 311: 75.51		SH3B4_HUMAN (1-963): 0: 1835: 100.00
+	Mm
		905357 1433G_MOUSE (3-246): 1.91e-109: 317: 75.40		SH3B4_MOUSE (1-963): 0: 1813: 91.60
+	Hs
		684365 1433S_HUMAN (3-239): 3.38e-100: 293: 68.62		SH3B4_HUMAN (1-963): 0: 1835: 100.00
+	Mm
		935606 1433F_MOUSE (4-244): 8.67e-108: 312: 75.51		SH3B4_MOUSE (1-963): 0: 1813: 91.60
+	Mm
		250874 1433S_MOUSE (3-234): 1.38e-97: 286: 68.38		SH3B4_MOUSE (1-963): 0: 1813: 91.60
+	Hs
		909710 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		MACC1_HUMAN (140-958): 0: 1340: 43.71