HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: NGAP (Q9UJF2)
Ras GTPase-activating protein nGAP (RAS protein activator-like 2)
Gene: RASAL2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.716

Property	Details
Experiments	33961781, 35271311, 36931259, 24255178, 28514442
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 246 Hs			1 1139
+	Hs
		910133 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		NGAP_HUMAN (1-1139): 0: 1051: 100.00
+	Hs
		927633 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		NGAP_HUMAN (1-1139): 0: 1051: 100.00
+	Hs
		909664 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		DAB2P_HUMAN (5-1138): 0: 963: 55.74
+	Hs
		683429 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		DAB2P_HUMAN (5-1138): 0: 963: 55.74
+	Hs
		927150 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		DAB2P_HUMAN (5-1138): 0: 963: 55.74
+	Mm
		99940 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		SYGP1_MOUSE (2-1138): 0: 768: 43.44
+	Hs
		909931 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		SYGP1_HUMAN (2-1138): 0: 765: 43.10
+	Hs
		683638 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		SYGP1_HUMAN (2-1138): 0: 765: 43.10
+	Mm
		99950 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		SYGP1_MOUSE (2-1138): 0: 768: 43.44
+	Hs
		927424 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		SYGP1_HUMAN (2-1138): 0: 765: 43.10
+	Hs
		909774 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		RASL3_HUMAN (9-789): 1.3e-163: 513: 34.82
+	Hs
		927262 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		RASL3_HUMAN (9-789): 1.3e-163: 513: 34.82
+	Hs
		683194 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		IQGA1_HUMAN (88-751): 2.04e-132: 443: 12.10
+	Hs
		809256 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		IQGA1_HUMAN (88-751): 2.04e-132: 443: 12.10
+	Hs
		598455 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		NF1_HUMAN (293-621): 8.74e-89: 317: 26.17
+	Mm
		910233 1433E_MOUSE (3-243): 4.39e-144: 405: 65.43		NF1_MOUSE (293-621): 1.28e-88: 317: 26.45
+	Hs
		598433 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		NF1_HUMAN (293-621): 8.74e-89: 317: 26.17
+	Mm
		926782 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		NF1_MOUSE (293-621): 1.28e-88: 317: 26.45
+	Hs
		598458 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		NF1_HUMAN (293-621): 8.74e-89: 317: 26.17
+	Hs
		598427 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		NF1_HUMAN (293-621): 8.74e-89: 317: 26.17