HitPredict

Interactor 1: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Interactor 2: KCC2A (Q9UQM7)
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CaM kinase II subunit alpha) (CaMK-II subunit alpha) (EC 2.7.11.17)
Gene: CAMK2A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	12619878
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 246 Hs			1 478
+	Hs
		910174 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KCC2A_HUMAN (1-478): 0: 565: 100.00
+	Mm
		515221 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		KCC2A_MOUSE (1-478): 0: 566: 99.79
+	Hs
		909532 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KCC2D_HUMAN (2-476): 0: 552: 87.37
+	Mm
		926819 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		KCC2D_MOUSE (2-476): 0: 552: 87.37
+	Hs
		647391 1433T_HUMAN (3-244): 3.24e-127: 361: 81.82		KCC2A_HUMAN (1-478): 0: 565: 100.00
+	Mm
		926866 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		KCC2G_MOUSE (1-476): 0: 524: 76.47
+	Mm
		659446 1433Z_MOUSE (3-244): 3.14e-142: 399: 88.02		KCC2B_MOUSE (1-476): 6.17e-179: 514: 71.11
+	Hs
		904532 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		KCC2D_HUMAN (2-476): 0: 552: 87.37
+	Hs
		684406 1433S_HUMAN (3-239): 3.38e-100: 293: 68.62		KCC2A_HUMAN (1-478): 0: 565: 100.00
+	Hs
		684020 1433S_HUMAN (3-239): 3.38e-100: 293: 68.62		KCC2D_HUMAN (2-476): 0: 552: 87.37
+	At
		965291 14332_ARATH (1-241): 4.75e-145: 407: 63.27		CDPK1_ARATH (5-406): 1.98e-148: 438: 29.34
+	At
		802001 14334_ARATH (2-241): 1.74e-141: 398: 61.07		CDPK1_ARATH (5-406): 1.98e-148: 438: 29.34
+	Hs
		159186 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		CSKP_HUMAN (9-307): 2.92e-85: 282: 46.08
+	Hs
		683325 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KCC2B_HUMAN (218-475): 1.27e-60: 211: 42.44
+	Hs
		909531 1433E_HUMAN (3-243): 4.39e-144: 405: 65.43		KCC2G_HUMAN (276-475): 3.97e-45: 167: 53.50
+	Hs
		683326 1433B_HUMAN (1-246): 3.48e-144: 404: 100.00		KCC2G_HUMAN (276-475): 3.97e-45: 167: 53.50
+	Hs
		927014 1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60		KCC2G_HUMAN (276-475): 3.97e-45: 167: 53.50
+	Hs
		904531 1433G_HUMAN (3-246): 1.91e-109: 317: 75.40		KCC2G_HUMAN (276-475): 3.97e-45: 167: 53.50
+	Hs
		981988 1433F_HUMAN (4-244): 2.7e-107: 311: 75.51		KCC2G_HUMAN (276-475): 3.97e-45: 167: 53.50