HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: NEDD4 (P46934)
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (Cell proliferation-inducing gene 53 protein) (HECT-type E3 ubiquitin transferase NEDD4) (Neural precursor cell expressed developmentally down-regulated protein 4) (NEDD-4)
Gene: NEDD4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	36931259
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0050815 - phosphoserine residue binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 1319
+	Hs
		808077 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		808081 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		646713 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		NEDD4_HUMAN (1-1319): 0: 1956: 100.00
+	Hs
		684276 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Mm
		910302 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		NED4L_MOUSE (517-1319): 0: 936: 62.42
+	Hs
		909930 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Mm
		93259 1433S_MOUSE (1-248): 4.84e-154: 429: 97.58		E9PXB7_MOUSE (539-1319): 0: 907: 62.80
+	Hs
		927423 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		NED4L_HUMAN (517-1319): 0: 934: 62.26
+	Mm
		93264 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		E9PXB7_MOUSE (539-1319): 0: 907: 62.80
+	Hs
		909745 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	Hs
		927228 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		HUWE1_HUMAN (799-1317): 6.4e-169: 562: 35.32
+	At
		788566 14333_ARATH (3-247): 2.63e-144: 405: 58.30		UPL2_ARATH (837-1316): 9.11e-162: 540: 35.60
+	Hs
		125183 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Hs
		125318 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Hs
		684266 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42
+	Hs
		125351 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Rn
		910358 1433E_RAT (2-246): 4.41e-146: 410: 60.41		NEDD4_RAT (433-678): 2.95e-16: 86.4: 16.23
+	Mm
		808343 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		NEDD4_MOUSE (433-678): 5.26e-14: 79.1: 16.29
+	Hs
		125169 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		WWP2_HUMAN (461-817): 1.56e-41: 167: 17.91
+	Hs
		647191 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		ITCH_HUMAN (468-799): 2.73e-28: 125: 19.42