HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: GRB10 (Q13322)
Growth factor receptor-bound protein 10 (GRB10 adapter protein) (Insulin receptor-binding protein Grb-IR)
Gene: GRB10

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	31980649, unassigned2173, 36931259
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 594
+	Hs
		909517 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		GRB10_HUMAN (1-594): 0: 712: 100.00
+	Hs
		927005 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		GRB10_HUMAN (1-594): 0: 712: 100.00
+	Hs
		684034 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		GRB7_HUMAN (107-594): 1.36e-174: 507: 55.60
+	Hs
		927204 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		RAPH1_HUMAN (34-484): 6.16e-107: 350: 23.94
+	Hs
		683994 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ITK_HUMAN (293-589): 1.9e-60: 213: 15.47
+	Hs
		909481 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ITK_HUMAN (293-589): 1.9e-60: 213: 15.47
+	Hs
		411616 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Hs
		411661 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Hs
		683883 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MATK_HUMAN (454-587): 1.29e-36: 144: 26.81
+	Hs
		411666 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Hs
		788960 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MATK_HUMAN (454-587): 1.29e-36: 144: 26.81
+	Hs
		782766 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		CSK_HUMAN (454-587): 2.23e-26: 114: 23.19
+	Hs
		909427 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		782768 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		CSK_HUMAN (454-587): 2.23e-26: 114: 23.19
+	Hs
		411605 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		LCK_HUMAN (420-589): 7.66e-49: 179: 19.66
+	Gg
		94492 1433E_CHICK (2-246): 4.41e-146: 410: 60.41		KSYK_CHICK (485-591): 1.81e-12: 72.1: 26.17
+	Hs
		924450 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Hs
		683181 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		CSK_HUMAN (454-587): 2.23e-26: 114: 23.19
+	Hs
		646781 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		GRB2_HUMAN (489-575): 3.64e-20: 91.4: 29.89
+	Gg
		94476 1433Z_CHICK (1-239): 2.54e-102: 298: 71.13		KSYK_CHICK (485-591): 1.81e-12: 72.1: 26.17