HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: PRAG1 (Q86YV5)
Inactive tyrosine-protein kinase PRAG1 (PEAK1-related kinase-activating pseudokinase 1) (Pragmin) (Sugen kinase 223) (SgK223)
Gene: PRAG1

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	36931259, 15778465
Identification Methods	cross-linking study, tandem affinity purification
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 248 Hs			1 1406
+	Hs
		909775 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		PRAG1_HUMAN (1-1406): 0: 2304: 100.00
+	Hs
		904814 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		PRAG1_HUMAN (1-1406): 0: 2304: 100.00
+	Hs
		982238 1433F_HUMAN (2-242): 2.78e-96: 283: 64.20		PRAG1_HUMAN (1-1406): 0: 2304: 100.00
+	Hs
		684328 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		PEAK1_HUMAN (14-104): 7.59e-10: 66: 40.43
+	Hs
		910032 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		PEAK1_HUMAN (14-104): 7.59e-10: 66: 40.43
+	Hs
		927534 1433Z_HUMAN (1-243): 5.4e-136: 384: 70.37		PEAK1_HUMAN (14-104): 7.59e-10: 66: 40.43
+	Hs
		647282 1433T_HUMAN (1-238): 9.98e-108: 312: 71.85		PEAK1_HUMAN (14-104): 7.59e-10: 66: 40.43
+	Hs
		683715 1433B_HUMAN (1-239): 3.41e-100: 293: 68.62		PEAK1_HUMAN (14-104): 7.59e-10: 66: 40.43
+	Hs
		905118 1433G_HUMAN (1-242): 1.86e-98: 289: 65.16		PEAK1_HUMAN (14-104): 7.59e-10: 66: 40.43
+	Hs
		982503 1433F_HUMAN (2-242): 2.78e-96: 283: 64.20		PEAK1_HUMAN (14-104): 7.59e-10: 66: 40.43