HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: KSR1 (Q8IVT5)
Kinase suppressor of Ras 1 (EC 2.7.11.1)
Gene: KSR1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	1.00	0.665

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology, cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 923
+	Hs
		909779 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		KSR1_HUMAN (1-923): 0: 765: 100.00
+	Mm
		910254 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		KSR1_MOUSE (1-923): 0: 715: 84.42
+	Mm
		926799 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		KSR1_MOUSE (1-923): 0: 715: 84.42
+	Hs
		909702 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		KSR2_HUMAN (33-898): 0: 577: 45.45
+	At
		248524 14331_ARATH (3-241): 4.5e-144: 405: 56.85		SIRK_ARATH (96-881): 1.27e-164: 505: 12.92
+	Hs
		542828 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		BRAF_HUMAN (252-914): 2.03e-148: 459: 22.80
+	Hs
		488591 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		ARAF_HUMAN (261-899): 1.38e-148: 454: 24.55
+	Mm
		250867 1433S_MOUSE (1-248): 4.84e-154: 429: 97.58		BRAF_MOUSE (252-914): 2.44e-148: 458: 22.95
+	Hs
		373772 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Hs
		110869 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		H7C560_HUMAN (252-914): 9.21e-149: 460: 22.80
+	Hs
		542849 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		BRAF_HUMAN (252-914): 2.03e-148: 459: 22.80
+	Mm
		655938 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		BRAF_MOUSE (252-914): 2.44e-148: 458: 22.95
+	Hs
		488645 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		ARAF_HUMAN (261-899): 1.38e-148: 454: 24.55
+	Gg
		982842 1433E_CHICK (2-246): 4.41e-146: 410: 60.41		BRAF_CHICK (252-914): 3.87e-145: 450: 23.10
+	Hs
		373995 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		RAF1_HUMAN (229-908): 9.62e-143: 440: 22.03
+	Mm
		655943 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		BRAF_MOUSE (252-914): 2.44e-148: 458: 22.95
+	Mm
		926872 1433Z_MOUSE (1-243): 1.34e-136: 385: 69.96		RAF1_MOUSE (232-908): 1.01e-140: 435: 22.40
+	Dm
		507708 1433E_DROME (2-247): 2.8e-144: 405: 58.07		KRAF1_DROME (251-908): 5.23e-117: 376: 20.48
+	Hs
		411616 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59
+	Hs
		411661 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		LCK_HUMAN (591-890): 2.14e-99: 322: 24.59