HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: NUAK2 (Q9H093)
NUAK family SNF1-like kinase 2 (EC 2.7.11.1) (Omphalocele kinase 2) (SNF1/AMP kinase-related kinase) (SNARK)
Gene: NUAK2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	32707033, 36931259
Identification Methods	affinity chromatography technology, pull down, cross-linking study
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 628
+	Hs
		910009 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NUAK2_HUMAN (1-628): 0: 592: 100.00
+	Hs
		684157 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK2_HUMAN (6-613): 9.9e-150: 453: 26.75
+	Mm
		910266 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		NUAK1_MOUSE (3-628): 3.21e-161: 478: 54.03
+	Hs
		229938 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		NUAK1_HUMAN (3-628): 2.28e-155: 463: 53.95
+	Hs
		647836 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		MARK3_HUMAN (5-625): 3.05e-141: 430: 25.54
+	Hs
		909730 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK2_HUMAN (6-613): 9.9e-150: 453: 26.75
+	Mm
		910234 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK2_MOUSE (6-613): 1.81e-146: 444: 26.79
+	Xl
		223345 O57468_XENLA (2-246): 5.73e-145: 407: 60.00		Q8QGV3_XENLA (4-613): 3.07e-145: 441: 26.14
+	Xl
		223344 O57468_XENLA (2-246): 5.73e-145: 407: 60.00		Q804T2_XENLA (5-625): 8.68e-145: 438: 24.85
+	Hs
		647862 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK3_HUMAN (5-625): 3.05e-141: 430: 25.54
+	Mm
		910231 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK3_MOUSE (5-625): 6.42e-140: 427: 25.25
+	Mm
		910308 1433E_MOUSE (2-246): 4.41e-146: 410: 60.41		MARK4_MOUSE (17-611): 8.46e-139: 424: 27.03
+	Hs
		909916 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		MARK4_HUMAN (17-611): 2.32e-138: 422: 27.19
+	At
		1280891 14337_ARATH (2-247): 4.35e-147: 413: 58.07		CIPKC_ARATH (28-377): 2.89e-137: 411: 32.11
+	At
		965360 14332_ARATH (3-248): 2.23e-144: 405: 58.47		CIPKC_ARATH (28-377): 2.89e-137: 411: 32.11
+	Hs
		684009 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		AAPK1_HUMAN (35-302): 1.31e-70: 240: 46.49
+	Hs
		683920 1433S_HUMAN (1-248): 3.48e-158: 440: 100.00		AAPK2_HUMAN (41-302): 5.22e-68: 233: 45.46
+	Rn
		871214 1433E_RAT (2-246): 4.41e-146: 410: 60.41		AAPK1_RAT (35-302): 1.32e-70: 240: 46.49
+	Hs
		909507 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AAPK1_HUMAN (35-302): 1.31e-70: 240: 46.49
+	Hs
		871354 1433E_HUMAN (2-246): 4.41e-146: 410: 60.41		AAPK2_HUMAN (41-302): 5.22e-68: 233: 45.46