HitPredict

Interactor 1: STIP1 (P31948)
Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)
Gene: STIP1

Interactor 2: FKBP5 (Q13451)
Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (54 kDa progesterone receptor-associated immunophilin) (Androgen-regulated protein 6) (FF1 antigen) (FK506-binding protein 5) (FKBP-5) (FKBP54) (p54) (HSP90-binding immunophilin) (Rotamase)
Gene: FKBP5

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	35271311, 21170051
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	TPR_1~TPR_11, TPR_11~TPR_6, TPR_1~TPR_12, TPR_1~TPR_2, TPR_1~TPR_8
Common GO terms	GO:0005829 - cytosol
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 543 Hs			1 457
+	Hs
		684646 STIP1_HUMAN (1-543): 2.75e-98: 309: 100.00		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		1034998 RPAP3_HUMAN (2-141): 4.46e-20: 96.1: 27.14		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		174855 OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		297056 TOM70_HUMAN (207-543): 4.08e-13: 73.8: 11.00		FKBP5_HUMAN (1-457): 6.63e-145: 423: 100.00
+	Hs
		174814 OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		118697 STIP1_HUMAN (1-543): 2.75e-98: 309: 100.00		AIP_HUMAN (144-414): 1.52e-49: 173: 16.72
+	Hs
		972498 IFT88_HUMAN (4-150): 8.37e-09: 60.3: 12.93		FKBP4_HUMAN (1-456): 1.79e-136: 402: 54.59
+	Hs
		684718 STIP1_HUMAN (1-543): 2.75e-98: 309: 100.00		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		684432 STIP1_HUMAN (1-543): 2.75e-98: 309: 100.00		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Dm
		817472 Q9VPN5_DROME (1-542): 1.4e-79: 259: 47.42		FKB12_DROME (153-247): 2.5e-20: 87.6: 26.26
+	Hs
		1012412 TMTC1_HUMAN (2-318): 1.14e-31: 132: 13.25		Q0VDC6_HUMAN (151-247): 5.97e-21: 90.6: 26.73
+	Hs
		684975 DNJC7_HUMAN (209-487): 3.28e-26: 113: 18.28		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		1053193 RPAP3_HUMAN (2-141): 4.46e-20: 96.1: 27.14		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		174884 OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57		FKBP8_HUMAN (25-330): 3.36e-27: 114: 19.23
+	Hs
		685029 RPAP3_HUMAN (2-141): 4.46e-20: 96.1: 27.14		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		174661 OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		213490 SGTA_HUMAN (202-327): 3.98e-09: 60.1: 32.54		STIP1_HUMAN (265-457): 3.91e-23: 104: 17.62
+	Hs
		175098 OGT1_HUMAN (5-261): 5.16e-18: 90: 13.57		FKB10_HUMAN (134-285): 5.25e-13: 72.9: 20.51