HitPredict

Interactor 1: COPG (P32074)
Coatomer subunit gamma (Gamma-coat protein) (Gamma-COP)
Gene: SEC21

Interactor 2: COPZ (P53600)
Coatomer subunit zeta (Zeta-coat protein) (Zeta-COP)
Gene: RET3

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	1.00	0.898

Property	Details
Experiments	18467557, 37968396, 22246286, 10921873
Identification Methods	protein complementation assay, affinity chromatography technology, x-ray crystallography, pull down, two hybrid, dihydrofolate reductase reconstruction
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Adaptin_N~Clat_adaptor_s
Common GO terms	GO:0000139 - Golgi membrane GO:0006886 - intracellular protein transport GO:0006890 - retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum GO:0006891 - intra-Golgi vesicle-mediated transport GO:0030126 - COPI vesicle coat
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 935 Sc			1 189
+	Hs
		902381 COPG2_HUMAN (7-933): 0: 666: 32.34		COPZ1_HUMAN (5-187): 2.43e-52: 167: 35.52
+	Hs
		1350198 COPG1_HUMAN (3-933): 0: 655: 31.71		COPZ2_HUMAN (5-187): 1.4e-55: 176: 32.24
+	Hs
		925992 AP2B1_HUMAN (3-925): 0: 672: 15.12		AP1M1_HUMAN (11-184): 1.85e-44: 154: 15.52
+	Hs
		902393 COPG1_HUMAN (3-933): 0: 655: 31.71		COPZ1_HUMAN (5-187): 2.43e-52: 167: 35.52
+	Hs
		926066 AP2B1_HUMAN (3-925): 0: 672: 15.12		AP1M2_HUMAN (11-184): 2.97e-43: 150: 15.52
+	Hs
		880408 AP2B1_HUMAN (3-925): 0: 672: 15.12		AP1S2_HUMAN (9-165): 6.2e-45: 147: 16.35
+	Hs
		903681 AP2B1_HUMAN (3-925): 0: 672: 15.12		AP1S1_HUMAN (9-171): 4.3e-44: 145: 15.39
+	Hs
		1014074 AP1B1_HUMAN (3-926): 0: 661: 15.33		AP1M1_HUMAN (11-184): 1.85e-44: 154: 15.52
+	Hs
		925978 AP2B1_HUMAN (3-925): 0: 672: 15.12		AP1S3_HUMAN (9-169): 1.02e-42: 142: 14.11
+	Hs
		1014107 AP1B1_HUMAN (3-926): 0: 661: 15.33		AP1M2_HUMAN (11-184): 2.97e-43: 150: 15.52
+	Hs
		880409 AP1B1_HUMAN (3-926): 0: 661: 15.33		AP1S2_HUMAN (9-165): 6.2e-45: 147: 16.35
+	Hs
		903682 AP1B1_HUMAN (3-926): 0: 661: 15.33		AP1S1_HUMAN (9-171): 4.3e-44: 145: 15.39
+	Hs
		864065 AP2B1_HUMAN (3-925): 0: 672: 15.12		AP2S1_HUMAN (9-159): 3.32e-39: 132: 13.73
+	Hs
		1014066 AP1B1_HUMAN (3-926): 0: 661: 15.33		AP1S3_HUMAN (9-169): 1.02e-42: 142: 14.11
+	Hs
		864070 AP1B1_HUMAN (3-926): 0: 661: 15.33		AP2S1_HUMAN (9-159): 3.32e-39: 132: 13.73
+	At
		1196570 APBLB_ARATH (1-933): 0: 638: 15.66		AP2S_ARATH (9-159): 1.08e-40: 136: 20.26
+	Dm
		1096906 Q24253_DROME (3-932): 0: 634: 14.00		Q9VDC3_DROME (9-159): 8.95e-42: 139: 13.73
+	Mm
		567520 AP2A2_MOUSE (6-935): 0: 616: 12.46		AP2S1_MOUSE (9-159): 5.08e-42: 139: 13.73
+	Hs
		321516 AP2A1_HUMAN (6-935): 0: 619: 11.75		AP2S1_HUMAN (9-159): 3.32e-39: 132: 13.73
+	Hs
		302125 AP2A2_HUMAN (6-933): 0: 616: 12.44		AP2S1_HUMAN (9-159): 3.32e-39: 132: 13.73