HitPredict

Interactor 1: ARRB2 (P32121)
Beta-arrestin-2 (Arrestin beta-2) (Non-visual arrestin-3)
Gene: ARRB2

Interactor 2: ARRC (P36575)
Arrestin-C (Cone arrestin) (C-arrestin) (cArr) (Retinal cone arrestin-3) (X-arrestin)
Gene: ARR3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.871

Property	Details
Experiments	28514442, 33961781, 17620599
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Arrestin_C~Arrestin_C, Arrestin_C~Arrestin_N, Arrestin_N~Arrestin_N
Common GO terms	GO:0001664 - G protein-coupled receptor binding GO:0002031 - G protein-coupled receptor internalization GO:0005737 - cytoplasm
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 409 Hs			1 388
+	Hs
		685845 ARRB2_HUMAN (1-409): 0: 688: 100.00		ARRB1_HUMAN (2-385): 0: 641: 57.18
+	Mm
		1207384 ARRB2_MOUSE (1-409): 0: 682: 96.34		ARRB1_MOUSE (2-376): 0: 629: 57.22
+	Hs
		827122 ARRB1_HUMAN (1-407): 0: 661: 76.15		ARRB1_HUMAN (2-385): 0: 641: 57.18
+	Hs
		685806 ARRB2_HUMAN (1-409): 0: 688: 100.00		ARRB2_HUMAN (2-379): 0: 591: 52.10
+	Rn
		663949 ARRB2_RAT (1-409): 0: 682: 95.85		ARRB2_RAT (2-379): 0: 586: 51.23
+	Hs
		736269 ARRB1_HUMAN (1-407): 0: 661: 76.15		ARRC_HUMAN (1-388): 0: 604: 100.00
+	Hs
		489848 ARRB2_HUMAN (1-409): 0: 688: 100.00		ARRS_HUMAN (4-386): 0: 566: 49.36
+	Hs
		489849 ARRB1_HUMAN (1-407): 0: 661: 76.15		ARRS_HUMAN (4-386): 0: 566: 49.36
+	Bt
		436867 ARRS_BOVIN (5-405): 0: 553: 51.46		ARRS_BOVIN (4-386): 0: 578: 49.87
+	Hs
		489847 ARRS_HUMAN (4-407): 0: 541: 51.91		ARRS_HUMAN (4-386): 0: 566: 49.36
+	Mm
		593478 ARRS_MOUSE (6-407): 0: 534: 51.33		ARRS_MOUSE (4-386): 0: 566: 51.93
+	Hs
		827233 ARRB1_HUMAN (1-407): 0: 661: 76.15		Q7Z3R3_HUMAN (175-359): 1.78e-91: 275: 48.65