HitPredict

Interactor 1: GRK4 (P32298)
G protein-coupled receptor kinase 4 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK4) (ITI1)
Gene: GRK4

Interactor 2: GRK6 (P43250)
G protein-coupled receptor kinase 6 (EC 2.7.11.16) (G protein-coupled receptor kinase GRK6)
Gene: GRK6

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.64 1.00 0.802

The method score is based on:

Property Details
Experiments 33961781, 32707033
Identification Methods affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase, Pkinase~RGS, RGS~RGS
Common GO terms GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0008277 - regulation of G protein-coupled receptor signaling pathway
GO:0009966 - regulation of signal transduction
and 1 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 578
Hs

1 576
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024