HitPredict

Interactor 1: IMB3 (P32337)
Importin subunit beta-3 (Karyopherin subunit beta-3) (Karyopherin-121) (Protein secretion enhancer 1)
Gene: PSE1

Interactor 2: GSP1 (P32835)
GTP-binding nuclear protein GSP1/CNR1 (Chromosome stability protein 17) (GTPase Ran homolog) (Genetic suppressor of PRP20-1)
Gene: GSP1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.971

Property	Details
Experiments	9214382, 11251069, 9891088, 18719252, 15679097, 17485461, 32484313, 34646016, 21329658
Identification Methods	affinity chromatography technology, two hybrid, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Importin_rep_4~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006606 - protein import into nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1089 Sc			1 219
+	Sc
		687909 IMB3_YEAST (1-1089): 3.51e-179: 555: 100.00		GSP2_YEAST (1-219): 9.33e-78: 234: 96.82
+	Hs
		236414 RNBP6_HUMAN (2-1087): 1.3e-169: 530: 26.32		RB11A_HUMAN (1-207): 4.63e-79: 237: 26.17
+	Sc
		698818 IMB4_YEAST (7-1076): 8.52e-100: 342: 18.75		GSP1_YEAST (1-219): 1.49e-79: 239: 100.00
+	Sc
		699008 IMB4_YEAST (7-1076): 8.52e-100: 342: 18.75		GSP2_YEAST (1-219): 9.33e-78: 234: 96.82
+	Hs
		919182 IPO4_HUMAN (22-1089): 6.37e-100: 342: 17.95		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	Dm
		1373317 Q9VRV8_DROME (202-1088): 1.01e-62: 232: 11.28		RANL_DROME (13-219): 2.1e-90: 266: 59.42
+	Hs
		919198 TNPO1_HUMAN (293-1089): 1.13e-68: 250: 11.87		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	Hs
		155560 TNPO2_HUMAN (214-1089): 4.77e-66: 242: 11.98		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	Sc
		698781 IMB2_YEAST (12-589): 3.14e-48: 188: 18.28		GSP1_YEAST (1-219): 1.49e-79: 239: 100.00
+	Sc
		698945 IMB1_YEAST (14-701): 1.06e-46: 183: 15.89		GSP1_YEAST (1-219): 1.49e-79: 239: 100.00
+	Sc
		699003 IMB2_YEAST (12-589): 3.14e-48: 188: 18.28		GSP2_YEAST (1-219): 9.33e-78: 234: 96.82
+	At
		784992 IMB1_ARATH (224-965): 3.34e-33: 140: 10.83		RAN1_ARATH (1-216): 6.84e-94: 275: 75.58
+	At
		784999 IMB1_ARATH (224-965): 3.34e-33: 140: 10.83		RAN2_ARATH (1-216): 1.74e-88: 261: 75.58
+	At
		1210454 IMB1_ARATH (224-965): 3.34e-33: 140: 10.83		RAN3_ARATH (1-219): 5.37e-84: 250: 74.55
+	At
		784988 TNPO1_ARATH (2-632): 2.33e-22: 105: 12.92		RAN1_ARATH (1-216): 6.84e-94: 275: 75.58
+	Hs
		127238 IPO5_HUMAN (3-679): 6.25e-18: 91.6: 10.34		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56
+	Hs
		919077 IMB1_HUMAN (610-1085): 3.63e-16: 85.8: 10.82		RAN_HUMAN (1-216): 3.71e-76: 230: 80.56