HitPredict

Interactor 1: IRE1 (P32361)
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]
Gene: IRE1

Interactor 2: IRE1 (P32361)
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]
Gene: IRE1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 23387983, 23541589, 14564015, 26792008, 25730376, 17452628, 34196665, 19079237, 18191223, 20625545, 21852455, 19079236
Identification Methods affinity chromatography technology, enzymatic study, fluorescent resonance energy transfer, pull down, x-ray crystallography, cosedimentation in solution, protein kinase assay
Interaction Type physical association, direct interaction, association, phosphorylation reaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase, Pkinase~Ribonuc_2-5A, Ribonuc_2-5A~Ribonuc_2-5A
Common GO terms GO:0004521 - RNA endonuclease activity
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
and 16 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 1115
Sc

1 1115
+ Hs
+ Hs
+ At
+ At
+ At
+ Gm
+ At
+ At
+ At
+ At
+ Hs
+ At
+ Hs
+ Hs
+ At
+ At
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024