HitPredict

Interactor 1: NAC1 (P32418)
Sodium/calcium exchanger 1 (Na(+)/Ca(2+)-exchange protein 1) (Solute carrier family 8 member 1)
Gene: SLC8A1

Interactor 2: S10AC (P80511)
Protein S100-A12 (CGRP) (Calcium-binding protein in amniotic fluid 1) (CAAF1) (Calgranulin-C) (CAGC) (Extracellular newly identified RAGE-binding protein) (EN-RAGE) (Migration inhibitory factor-related protein 6) (MRP-6) (p6) (Neutrophil S100 protein) (S100 calcium-binding protein A12) [Cleaved into: Calcitermin]
Gene: S100A12

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	31837246
Identification Methods	fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 973 Hs			1 92
+	Hs
		638928 NAC1_HUMAN (1-973): 0: 1131: 100.00		S100P_HUMAN (1-91): 4.22e-34: 114: 45.06
+	Hs
		685156 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10AB_HUMAN (2-91): 6.03e-34: 114: 36.67
+	Hs
		615205 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10A1_HUMAN (2-91): 2.44e-33: 112: 37.78
+	Hs
		380746 NAC1_HUMAN (1-973): 0: 1131: 100.00		S100B_HUMAN (1-92): 3.09e-30: 104: 38.04
+	Hs
		416365 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10A9_HUMAN (1-91): 2.97e-30: 104: 46.74
+	Hs
		642918 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10A4_HUMAN (3-90): 2.12e-30: 104: 34.09
+	Hs
		689707 NAC1_HUMAN (1-973): 0: 1131: 100.00		S100Z_HUMAN (2-92): 6.17e-30: 103: 39.56
+	Hs
		661206 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10A2_HUMAN (2-90): 1.46e-29: 102: 35.96
+	Hs
		689702 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10AA_HUMAN (2-89): 1.9e-29: 102: 31.82
+	Hs
		689700 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10A3_HUMAN (3-89): 2.61e-28: 99.5: 32.18
+	Hs
		396691 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10A8_HUMAN (1-92): 6.32e-26: 93.3: 38.04
+	Hs
		416580 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10A6_HUMAN (3-87): 3.68e-24: 88.7: 37.65
+	Hs
		689699 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10A5_HUMAN (2-92): 1.07e-22: 85.2: 35.17
+	Hs
		689708 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10AD_HUMAN (1-83): 1.32e-21: 82.6: 34.94
+	Hs
		689709 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10AE_HUMAN (2-84): 1.66e-20: 79.9: 28.92
+	Hs
		689706 NAC1_HUMAN (1-973): 0: 1131: 100.00		S1A7A_HUMAN (2-90): 8.2e-20: 77.9: 26.37
+	Hs
		678415 NAC1_HUMAN (1-973): 0: 1131: 100.00		S10A7_HUMAN (2-90): 8.85e-19: 75.6: 26.37
+	Hs
		666669 NAC1_HUMAN (1-973): 0: 1131: 100.00		S100G_HUMAN (6-82): 4.76e-17: 70.3: 36.36