HitPredict

Interactor 1: ASF1 (P32447)
Histone chaperone ASF1 (Anti-silencing function protein 1) (yASF1)
Gene: ASF1

Interactor 2: HIR1 (P32479)
Protein HIR1 (Histone transcription regulator 1)
Gene: HIR1

Species: Saccharomyces cerevisiae S288C

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	1.00	0.968

Property	Details
Experiments	11404324, 11412995, 16554755, 16303565, 24824343, 37968396, 20048053, 21179020
Identification Methods	two hybrid, affinity chromatography technology, pull down, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	ASF1_hist_chap~HIRA_B
Common GO terms	GO:0005634 - nucleus GO:0006325 - chromatin organization GO:0006334 - nucleosome assembly
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 279 Sc			1 840
+	Hs
		867897 ASF1B_HUMAN (1-167): 4.44e-107: 310: 55.36		HIRA_HUMAN (1-838): 1.27e-121: 393: 19.98
+	Xl
		1148535 AS1AA_XENLA (1-175): 4.88e-101: 295: 53.67		HIRA_XENLA (1-838): 1.88e-120: 390: 20.18
+	Hs
		867906 ASF1A_HUMAN (1-158): 3.13e-99: 290: 57.60		HIRA_HUMAN (1-838): 1.27e-121: 393: 19.98
+	Gg
		945614 ASF1_CHICK (1-158): 3.13e-99: 290: 57.60		HIRA_CHICK (1-838): 2.58e-119: 387: 19.94
+	At
		1321245 ASF1A_ARATH (1-195): 1.5e-103: 301: 48.72		HIRA_ARATH (1-837): 7.08e-114: 372: 21.30
+	Sp
		251629 ASF1_SCHPO (1-169): 1.68e-88: 265: 62.29		HIR1_SCHPO (1-836): 5.17e-116: 376: 30.00
+	Dm
		184546 ASF1_DROME (1-182): 4.94e-96: 283: 49.74		HIRA_DROME (1-838): 8.59e-99: 332: 21.04
+	Hs
		1024600 ASF1B_HUMAN (1-167): 4.44e-107: 310: 55.36		CAF1B_HUMAN (1-553): 1.51e-83: 279: 21.25
+	Sc
		689955 ASF1_YEAST (1-279): 1.29e-110: 322: 100.00		CAC2_YEAST (1-447): 1.34e-76: 258: 19.28
+	Xl
		993165 AS1AA_XENLA (1-175): 4.88e-101: 295: 53.67		Q07CZ6_XENLA (1-564): 1.95e-83: 279: 22.99
+	Gg
		1107997 ASF1_CHICK (1-158): 3.13e-99: 290: 57.60		CAF1B_CHICK (1-580): 6.66e-85: 283: 20.86
+	Hs
		1024612 ASF1A_HUMAN (1-158): 3.13e-99: 290: 57.60		CAF1B_HUMAN (1-553): 1.51e-83: 279: 21.25
+	Dm
		53064 ASF1_DROME (1-182): 4.94e-96: 283: 49.74		A1Z898_DROME (1-649): 3.22e-81: 278: 19.22
+	Sp
		144001 ASF1_SCHPO (1-169): 1.68e-88: 265: 62.29		YEG3_SCHPO (1-447): 9.55e-57: 205: 19.93
+	Sc
		689847 ASF1_YEAST (1-279): 1.29e-110: 322: 100.00		HIR2_YEAST (286-838): 1.31e-24: 112: 15.25
+	Sc
		689868 ASF1_YEAST (1-279): 1.29e-110: 322: 100.00		TAF5_YEAST (36-206): 6.35e-09: 61.6: 24.42
+	Hs
		1288338 ASF1B_HUMAN (1-167): 4.44e-107: 310: 55.36		SNR40_HUMAN (431-768): 2.4e-11: 68.3: 9.33
+	Sp
		251229 ASF1_SCHPO (1-169): 1.68e-88: 265: 62.29		SLM9_SCHPO (17-248): 6.27e-12: 71.5: 17.05