HitPredict

Interactor 1: HIR2 (P32480)
Protein HIR2 (Histone transcription regulator 2)
Gene: HIR2

Interactor 2: H3 (P61830)
Histone H3
Gene: HHT1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	0.60	0.633

Property	Details
Experiments	14651846, 22922743, 21179020
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 875 Sc			1 136
+	Sc
		690871 HIR2_YEAST (1-875): 0: 583: 100.00		CENPA_YEAST (24-134): 7.32e-41: 137: 53.04
+	Sc
		690852 HIR1_YEAST (1-542): 6.88e-84: 288: 17.77		H3_YEAST (1-136): 1.51e-56: 174: 100.00
+	Dm
		53056 A1Z898_DROME (7-513): 3.11e-72: 254: 14.21		H3_DROME (1-136): 6.6e-61: 185: 88.97
+	Sc
		902046 CAC2_YEAST (63-409): 1.11e-58: 209: 18.80		H3_YEAST (1-136): 1.51e-56: 174: 100.00
+	Hs
		903117 WDR5_HUMAN (4-350): 6.32e-53: 189: 11.68		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		903128 WDR5_HUMAN (4-350): 6.32e-53: 189: 11.68		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		903260 WDR5_HUMAN (4-350): 6.32e-53: 189: 11.68		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Sc
		730914 CAC2_YEAST (63-409): 1.11e-58: 209: 18.80		CENPA_YEAST (24-134): 7.32e-41: 137: 53.04
+	Hs
		867850 HIRA_HUMAN (202-540): 5.57e-28: 123: 10.24		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		867853 HIRA_HUMAN (202-540): 5.57e-28: 123: 10.24		H33_HUMAN (1-136): 1.25e-61: 187: 90.44
+	Hs
		867878 HIRA_HUMAN (202-540): 5.57e-28: 123: 10.24		H32_HUMAN (1-136): 6.6e-61: 185: 88.97
+	Mm
		952748 HIRA_MOUSE (275-644): 2.4e-24: 111: 10.57		H33_MOUSE (1-136): 1.25e-61: 187: 90.44
+	Hs
		935208 TBL1R_HUMAN (386-749): 1.18e-19: 95.3: 9.65		H31_HUMAN (1-136): 3.24e-62: 188: 88.97
+	Hs
		792992 LIS1_HUMAN (440-738): 1.31e-19: 94.1: 8.11		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Hs
		245614 TBL1X_HUMAN (504-752): 1.23e-14: 79.9: 9.38		H32_HUMAN (1-136): 6.6e-61: 185: 88.97
+	At
		886471 HIRA_ARATH (8-188): 2.99e-12: 72.9: 9.43		H33_ARATH (1-136): 4.81e-62: 187: 87.50
+	Hs
		274359 WDHD1_HUMAN (317-549): 1.34e-12: 74.1: 7.38		H32_HUMAN (1-136): 6.6e-61: 185: 88.97
+	Hs
		828179 HIRA_HUMAN (202-540): 5.57e-28: 123: 10.24		CENPA_HUMAN (9-133): 2.55e-40: 133: 47.73
+	Hs
		152879 APAF_HUMAN (8-101): 3.62e-11: 69.5: 11.34		H31T_HUMAN (1-136): 1.96e-61: 186: 86.03
+	Sc
		730915 SEC13_YEAST (133-397): 3.43e-14: 76.1: 14.95		CENPA_YEAST (24-134): 7.32e-41: 137: 53.04