HitPredict

Interactor 1: A9UF07 (A9UF07)
non-specific protein-tyrosine kinase (EC 2.7.10.2)
Gene: BCR/ABL

Interactor 2: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.39	1.00	0.625

Property	Details
Experiments	19380743
Identification Methods	tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PI3K_P85_iSH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1790 Hs			1 728
+	Hs
		69202 A9UF07_HUMAN (1-1790): 0: 2099: 100.00		P85A_HUMAN (606-721): 5.69e-21: 100: 28.81
+	Hs
		69206 A9UF07_HUMAN (1-1790): 0: 2099: 100.00		GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40
+	Hs
		129151 ABL1_HUMAN (688-1790): 0: 938: 100.00		P85B_HUMAN (1-728): 0: 549: 100.00
+	Hs
		337384 ABL1_HUMAN (688-1790): 0: 938: 100.00		ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28
+	Hs
		337307 ABL1_HUMAN (688-1790): 0: 938: 100.00		FYN_HUMAN (556-721): 1.61e-31: 131: 20.69
+	Hs
		337440 ABL1_HUMAN (688-1790): 0: 938: 100.00		BTK_HUMAN (551-727): 5.38e-31: 131: 20.65
+	Hs
		337293 ABL1_HUMAN (688-1790): 0: 938: 100.00		ABL1_HUMAN (532-725): 2.04e-30: 130: 21.54
+	Hs
		337315 ABL1_HUMAN (688-1790): 0: 938: 100.00		HCK_HUMAN (551-724): 1.01e-30: 128: 22.53
+	Hs
		337329 ABL1_HUMAN (688-1790): 0: 938: 100.00		SRC_HUMAN (535-728): 1.04e-28: 123: 18.81
+	Hs
		337356 ABL1_HUMAN (688-1790): 0: 938: 100.00		P85A_HUMAN (606-721): 5.69e-21: 100: 28.81
+	Hs
		337333 ABL1_HUMAN (688-1790): 0: 938: 100.00		VAV_HUMAN (621-719): 3.02e-14: 78.7: 34.00
+	Hs
		337418 ABL1_HUMAN (688-1790): 0: 938: 100.00		GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40
+	Mm
		337619 ABL1_MOUSE (688-1790): 0: 857: 86.45		PTN11_MOUSE (622-723): 5.25e-12: 71: 24.56
+	Hs
		789042 ABL2_HUMAN (670-1790): 0: 727: 52.11		ABL2_HUMAN (545-725): 5.17e-31: 132: 25.28
+	Hs
		412070 ABL2_HUMAN (670-1790): 0: 727: 52.11		FYN_HUMAN (556-721): 1.61e-31: 131: 20.69
+	Hs
		442789 ABL2_HUMAN (670-1790): 0: 727: 52.11		HCK_HUMAN (551-724): 1.01e-30: 128: 22.53
+	Hs
		522840 ABL2_HUMAN (670-1790): 0: 727: 52.11		SRC_HUMAN (535-728): 1.04e-28: 123: 18.81
+	Hs
		655254 ABL2_HUMAN (670-1790): 0: 727: 52.11		P85A_HUMAN (606-721): 5.69e-21: 100: 28.81
+	Hs
		789054 ABL2_HUMAN (670-1790): 0: 727: 52.11		GRB2_HUMAN (329-411): 1.45e-14: 75.2: 31.40