HitPredict

Interactor 1: A9UF07 (A9UF07)
non-specific protein-tyrosine kinase (EC 2.7.10.2)
Gene: BCR/ABL

Interactor 2: SHC1 (P29353)
SHC-transforming protein 1 (SHC-transforming protein 3) (SHC-transforming protein A) (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.39	1.00	0.625

Property	Details
Experiments	19380743
Identification Methods	tandem affinity purification, anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, SH2~SH2, SH2~SH3_1
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1790 Hs			1 583
+	Hs
		69202 A9UF07_HUMAN (1-1790): 0: 2099: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		69198 A9UF07_HUMAN (1-1790): 0: 2099: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		69206 A9UF07_HUMAN (1-1790): 0: 2099: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Hs
		337362 ABL1_HUMAN (688-1790): 0: 938: 100.00		SHC1_HUMAN (1-583): 0: 531: 100.00
+	Hs
		337333 ABL1_HUMAN (688-1790): 0: 938: 100.00		VAV_HUMAN (163-578): 1.81e-54: 200: 12.25
+	Hs
		337531 ABL1_HUMAN (688-1790): 0: 938: 100.00		SHD_HUMAN (328-582): 1.62e-47: 171: 23.02
+	Hs
		337315 ABL1_HUMAN (688-1790): 0: 938: 100.00		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Hs
		337483 ABL1_HUMAN (688-1790): 0: 938: 100.00		SHB_HUMAN (369-579): 2.01e-41: 158: 20.63
+	Hs
		337337 ABL1_HUMAN (688-1790): 0: 938: 100.00		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		275520 ABL1_HUMAN (688-1790): 0: 938: 100.00		BCAR3_HUMAN (379-583): 3.82e-38: 152: 23.83
+	Hs
		337356 ABL1_HUMAN (688-1790): 0: 938: 100.00		P85A_HUMAN (300-581): 2.38e-38: 152: 15.31
+	Hs
		337491 ABL1_HUMAN (688-1790): 0: 938: 100.00		SHE_HUMAN (357-583): 9.82e-38: 148: 21.40
+	Hs
		129151 ABL1_HUMAN (688-1790): 0: 938: 100.00		P85B_HUMAN (358-581): 2.69e-29: 125: 17.47
+	Hs
		337418 ABL1_HUMAN (688-1790): 0: 938: 100.00		GRB2_HUMAN (482-578): 1.65e-15: 77.5: 30.48
+	Mm
		337637 ABL1_MOUSE (688-1790): 0: 857: 86.45		NCK1_MOUSE (360-575): 1.9e-41: 155: 18.30
+	Hs
		337466 ABL1_HUMAN (688-1790): 0: 938: 100.00		GRAP_HUMAN (482-578): 1.45e-13: 72.2: 25.71
+	Hs
		209001 ABL2_HUMAN (670-1790): 0: 727: 52.11		NCK2_HUMAN (363-579): 5.31e-45: 165: 18.83
+	Hs
		442789 ABL2_HUMAN (670-1790): 0: 727: 52.11		HCK_HUMAN (348-575): 2.72e-43: 164: 17.16
+	Hs
		557630 ABL2_HUMAN (670-1790): 0: 727: 52.11		NCK1_HUMAN (360-575): 1.55e-41: 155: 18.30
+	Hs
		275550 ABL2_HUMAN (670-1790): 0: 727: 52.11		BCAR3_HUMAN (379-583): 3.82e-38: 152: 23.83