HitPredict

Interactor 1: ELF1 (P32519)
ETS-related transcription factor Elf-1 (E74-like factor 1)
Gene: ELF1

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35140242
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 619 Hs			1 3969
+	Hs
		975263 ELF2_HUMAN (2-615): 5.36e-71: 242: 34.13		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		692200 ELF1_HUMAN (1-619): 3.15e-93: 301: 100.00		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		1077618 ELF2_HUMAN (2-615): 5.36e-71: 242: 34.13		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		1304910 ELF4_HUMAN (1-587): 2.82e-46: 175: 36.91		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		785424 ELK3_HUMAN (223-598): 7.48e-41: 155: 21.45		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		165637 ELF1_HUMAN (1-619): 3.15e-93: 301: 100.00		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		507437 ERG_HUMAN (91-375): 7.36e-43: 162: 21.75		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		165681 ELF2_HUMAN (2-615): 5.36e-71: 242: 34.13		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		165710 ELF4_HUMAN (1-587): 2.82e-46: 175: 36.91		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		165644 ELK3_HUMAN (223-598): 7.48e-41: 155: 21.45		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		165709 FEV_HUMAN (190-404): 1.77e-42: 154: 26.39		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		152583 ETS1_HUMAN (14-313): 1.66e-52: 188: 24.50		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		152604 ETV5_HUMAN (109-324): 9.59e-49: 179: 25.11		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		152681 ELF4_HUMAN (1-587): 2.82e-46: 175: 36.91		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		1243851 ELF5_HUMAN (65-294): 8.13e-46: 165: 21.30		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		507468 ERG_HUMAN (91-375): 7.36e-43: 162: 21.75		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		152699 ELF5_HUMAN (65-294): 8.13e-46: 165: 21.30		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		152581 ERG_HUMAN (91-375): 7.36e-43: 162: 21.75		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		152607 ETV4_HUMAN (195-353): 1e-40: 156: 32.72		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		152680 FEV_HUMAN (190-404): 1.77e-42: 154: 26.39		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47